FGFR4

fibroblast growth factor receptor 4

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

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Products

ELISA Kits (12)

Type

Sandwich (11)

Sandwich CLIA (1)

Target

FGFR4 (12)

Reactivity

Human (5)

Mouse (1)

Chicken (1)

Guinea pig (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Sheep (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (9)

Publications

No (12)

Sample Type

Cell Culture Supernatants (1)

Cell Supernatant (1)

Citrate Plasma (1)

EDTA Plasma (1)

Heparin Plasma (1)

Plasma (4)

Serum (5)

Tissue Homogenates (2)

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Human FGFR4 (Sandwich ELISA) ELISA Kit - LS-F20899

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$610

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Human FGFR4 (CLIA) ELISA Kit - LS-F29323

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Chicken FGFR4 (Sandwich ELISA) ELISA Kit - LS-F43941

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Monkey FGFR4 (Sandwich ELISA) ELISA Kit - LS-F43944

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Guinea pig FGFR4 (Sandwich ELISA) ELISA Kit - LS-F43943

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Porcine FGFR4 (Sandwich ELISA) ELISA Kit - LS-F43945

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Rabbit FGFR4 (Sandwich ELISA) ELISA Kit - LS-F43946

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Sheep FGFR4 (Sandwich ELISA) ELISA Kit - LS-F43947

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$760

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Human FGFR4 (Sandwich ELISA) ELISA Kit - LS-F34641

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human FGFR4 (Sandwich ELISA) ELISA Kit - LS-F74758

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78.13 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Supernatant, Plasma, Serum

Price:

1 Plate/$598

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Mouse FGFR4 (Sandwich ELISA) ELISA Kit - LS-F57199

Type:

Sandwich

Reactivity:

Mouse

Range:

312 - 20000 pg/ml

Sample Types:

Cell Culture Supernatants, Citrate Plasma, EDTA Plasma, Heparin Plasma, Serum

Price:

1 Plate/$1,150

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Human FGFR4 (Sandwich ELISA) ELISA Kit - LS-F6633

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$798

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