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FGFR3

fibroblast growth factor receptor 3

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.

Gene Name: fibroblast growth factor receptor 3
Family/Subfamily: Protein Kinase , FGF Receptor
Synonyms: FGFR3, CD333, CD333 antigen, ACH, FGF receptor 3, HSFGFR3EX, Hydroxyaryl-protein kinase, JTK4, FGFR-3, CEK2, Tyrosine kinase JTK4
Target Sequences: NM_000142 NP_000133.1 P22607

Publications (1)

1
Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System. Bunney TD, Inglis AJ, Sanfelice D, Farrell B, Kerr CJ, Thompson GS, Masson GR, Thiyagarajan N, Svergun DI, Williams RL, Breeze AL, Katan M. Structure. 2018 March;26:446-458. (Mouse) [Full Text Article] [PubMed:29478821] [PMC:PMC5846801] Related Antibodies: LS-C214248.

☰ Filters
Products
Proteins (19)
Over-Expression Lysate (2)
Recombinant (17)
FGFR3 (19)
No (19)
6His, C-terminus (2)
6His, N-terminus (2)
6His-B2M, N-terminus (1)
Fc (1)
Fc, C-terminus (2)
GST, N-terminus (1)
His (2)
His,C-terminus (1)
His-Fc (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (16)
Mouse (2)
293T Cells (1)
CHO Cells (1)
E. coli (3)
HEK 293 Cells (3)
Human (1)
Human Cells (4)
Mammalian Cells (3)
Wheat Germ Extract (1)
Yeast (2)
Purified (4)
Low endotoxin level (9)
Biologically active (2)
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39kD
10 µg/$277; 50 µg/$395; 500 µg/$1,262; 1 mg/$1,627
FGFR3 Protein
Select
Yeast
His
40.1 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
Select
E. coli
6His, N-terminus
42.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
FGFR3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
FGFR3 Protein - Recombinant Fibroblast Growth Factor Receptor 3 By SDS-PAGE
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E. coli
His-T7
26.8 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
FGFR3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
87.71 kDa
100 µg/$710
Select
CHO Cells
None
Biologically active
128.3 kDa or 100-110 kDa
10 µg/$268; 50 µg/$349
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37 kDa
100 µg/$843
FGFR3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
87.71 kDa
20 µg/$215
FGFR3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-B2M, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
FGFR3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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Human Cells
His-Fc
Less than 1.0 EU/µg protein (determined by LAL method).
66 kDa
100 µg/$721
FGFR3 Protein - Purified recombinant protein FGFR3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
85.7 kDa
20 µg/$1,107
FGFR3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
Fc, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
64.8 kDa
50 µg/$356; 10 µg/$284; 1 mg/$1,935; 500 µg/$1,470
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
64.8 kDa
10 µg/$266; 50 µg/$317
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39 kDa
10 µg/$277; 50 µg/$389
Select
Human
None
Less than 1.0 EU/µg protein (determined by LAL method).
64.8kD
10 µg/$266; 50 µg/$321; 500 µg/$1,203; 1 mg/$1,557
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
40 kDa
200 µg/$1,148
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
65.3 kDa
200 µg/$1,148
Viewing 1-19 of 19 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).