FGFR2 / FGF Receptor 2

fibroblast growth factor receptor 2

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

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Products

Proteins (13)

Type

Over-Expression Lysate (4)

Recombinant (9)

Target

FGFR2 / FGF Receptor 2 (13)

Publications

No (13)

Tag

DDK (Flag)-His, C-terminus (1)

DDK,C-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His-Fc (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (11)

Source

293T Cells (2)

Baculovirus (1)

E. coli (1)

HEK 293 Cells (4)

Human Cells (2)

Sf9 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (3)

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Human FGFR2 / FGF Receptor 2 Protein (Recombinant GST) (Full Length) - LS-G28468

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

105.27 kDa

Price:

10 µg/$479; 25 µg/$670

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Human FGFR2 / FGF Receptor 2 Protein (Recombinant DDK,C-terminus) - LS-G142362

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

39.5 kDa

Price:

20 µg/$677

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Human FGFR2 / FGF Receptor 2 Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142203

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

42 kDa

Price:

20 µg/$1,107

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Human FGFR2 / FGF Receptor 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75913

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

92.5 kDa

Price:

20 µg/$215

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Human FGFR2 / FGF Receptor 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75914

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.8 kDa

Price:

20 µg/$215

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Human FGFR2 / FGF Receptor 2 Protein (Recombinant GST, N-terminus) (aa621-723) - LS-G58564

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human FGFR2 / FGF Receptor 2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65626

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.7 kDa

Price:

20 µg/$1,107

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FGFR2 / FGF Receptor 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G98935

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

92.5 kDa

Price:

100 µg/$710

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FGFR2 / FGF Receptor 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101846

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.8 kDa

Price:

100 µg/$710

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Human FGFR2 / FGF Receptor 2 Protein (Recombinant His-Fc) (Met1-Glu377) - LS-G97472

Source:

Human Cells

Tag:

His-Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

67.6 kDa

Price:

100 µg/$721

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Human FGFR2 / FGF Receptor 2 Protein (Recombinant His-GST) (Met400-Thr821) - LS-G97469

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

75.7 kDa

Price:

50 µg/$707

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Human FGFR2 / FGF Receptor 2 Protein (Recombinant His) (Met1-Glu377) - LS-G97470

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

41 kDa

Price:

100 µg/$721

Select

Human FGFR2 / FGF Receptor 2 Protein (Recombinant His-T7) (aa157-377) - LS-G14284

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.4 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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