FGFR2 / FGF Receptor 2

fibroblast growth factor receptor 2

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

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Products

ELISA Kits (11)

Type

Cell-Based (1)

Sandwich (9)

Sandwich CLIA (1)

Target

FGFR2 / FGF Receptor 2 (11)

Reactivity

Human (5)

Mouse (1)

Rat (1)

Chicken (1)

Guinea pig (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Sheep (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (2)

96-Well Strip Plate (8)

Publications

No (11)

Sample Type

Adherent Cell Cultures (1)

Plasma (4)

Serum (4)

Tissue Homogenates (2)

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Human FGFR2 / FGF Receptor 2 (Sandwich ELISA) ELISA Kit - LS-F34640

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Chicken FGFR2 / FGF Receptor 2 (Sandwich ELISA) ELISA Kit - LS-F43931

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

1.563 - 100 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Guinea pig FGFR2 / FGF Receptor 2 (Sandwich ELISA) ELISA Kit - LS-F43932

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

1.563 - 100 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Porcine FGFR2 / FGF Receptor 2 (Sandwich ELISA) ELISA Kit - LS-F43935

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Monkey FGFR2 / FGF Receptor 2 (Sandwich ELISA) ELISA Kit - LS-F43934

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Sheep FGFR2 / FGF Receptor 2 (Sandwich ELISA) ELISA Kit - LS-F43936

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$760

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Rabbit FGFR2 / FGF Receptor 2 (Sandwich ELISA) ELISA Kit - LS-F43937

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

1.25 - 80 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Human FGFR2 / FGF Receptor 2 (CLIA) ELISA Kit - LS-F29194

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

12.5 - 800 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human FGFR2 / FGF Receptor 2 (Sandwich ELISA) ELISA Kit - LS-F23413

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human FGFR2 / FGF Receptor 2 (Sandwich ELISA) ELISA Kit - LS-F6521

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$798

Select

Mouse/Human/Rat FGFR2 / FGF Receptor 2 (Cell-Based ELISA) ELISA Kit - LS-F1989

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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