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FGFR1 / FGF Receptor 1
fibroblast growth factor receptor 1
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
| Gene Name: | fibroblast growth factor receptor 1 |
| Family/Subfamily: | Protein Kinase , FGF Receptor |
| Synonyms: | FGFR1, BFGF receptor, BFGF-R, BFGF-R-1, CD331, Cek1, CD331 antigen, FGFR1/PLAG1 fusion, FLT2, Fgf-flg, FGFBR, FGFR-1, Fms-like tyrosine kinase 2, HBGFR, HH2, Hydroxyaryl-protein kinase, FGF receptor 1, Fms-related tyrosine kinase 2, Proto-oncogene c-Fgr, BFGFR, CEK, FLT-2, HBGF receptor, KAL2, OGD |
| Target Sequences: | NM_023110 CAA47375.1 P11362 |
Publications (5)
1
PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and o. Ng F, Boucher S, Koh S, Sastry KS, Chase L, Lakshmipathy U, Choong C, Yang Z, Vemuri MC, Rao MS, Tanavde V. Blood. 2008 112:295-307.
[PubMed:18332228]
2
Ureteral obstruction promotes proliferation and differentiation of the renal urothelium into a bladder-like phenotype. Girshovich A, Vinsonneau C, Perez J, Vandermeersch S, Verpont MC, Placier S, Jouanneau C, Letavernier E, Baud L, Haymann JP. Kidney international. 2012 82:428-35.
[PubMed:22513823]
3
Transmembrane proteoglycans syndecan-2, 4, receptor candidates for the impact of HGF and FGF2 on semaphorin 3A expression in early-differentiated myoblasts. Do MK, Shimizu N, Suzuki T, Ohtsubo H, Mizunoya W, Nakamura M, Sawano S, Furuse M, Ikeuchi Y, Anderson JE, Tatsumi R. Physiological reports. 2015 3: (WB; Human)
[Full Text Article]
[PubMed:26381016]
[PMC:PMC4600393]
Related Antibodies: LS-C23658.
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FGFR1 / FGF Receptor 1 Mouse anti-Human Monoclonal (N-Terminus) (M2F12) Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$555
FGFR1 / FGF Receptor 1 Mouse anti-Human Monoclonal (N-Terminus) (M 17A3) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µg/$555
FGFR1 / FGF Receptor 1 Mouse anti-Human Monoclonal (N-Terminus) (M19B2) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
125 µg/$485
FGFR1 / FGF Receptor 1 Mouse anti-Human Monoclonal (aa179-195) (M17D10) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
125 µg/$485
FGFR1 / FGF Receptor 1 Goat anti-Human Polyclonal (aa837-852) Antibody
Dog, Bovine, Horse, Bat, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
FGFR1 / FGF Receptor 1 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Mouse, Human
FLISA, Flo, IF, IHC, WB
FITC Conjugated
200 µl/$952
FGFR1 / FGF Receptor 1 Rabbit anti-Human Polyclonal (N-Terminus) (PE) Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC, IP, WB
PE Conjugated
200 µl/$952
FGFR1 / FGF Receptor 1 Rabbit anti-Human Polyclonal (N-Terminus) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC, IP, WB
HRP Conjugated, Azide-free
200 µl/$952
FGFR1 / FGF Receptor 1 Mouse anti-Bovine Monoclonal (VBS-7) Antibody
Chicken, Bovine, Mouse, Guinea pig, Rat, Human
ELISA, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$786
FGFR1 / FGF Receptor 1 Rabbit anti-Human Polyclonal (aa736-785) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
FGFR1 / FGF Receptor 1 Mouse anti-Human Monoclonal (N-Terminus) Antibody
Human
Flo, IP, WB
Unconjugated
100 µg/$649
FGFR1 / FGF Receptor 1 Mouse anti-Human Monoclonal (aa23-325) Antibody
Rat, Human
IP, WB
Unconjugated
50 µg/$444; 250 µg/$839
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
FGFR1 / FGF Receptor 1 Rabbit anti-Human Polyclonal Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
FGFR1 / FGF Receptor 1 Mouse anti-Human Monoclonal Antibody
Chicken, Bovine, Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
100 µg/$826
FGFR1 / FGF Receptor 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
Human FGFR1 / FGF Receptor 1 Protein (Recombinant His,N-terminus + GST) (Gly311-Arg731) - LS-G140006
Insect Cells
His,N-terminus + GST
Less than 1.0 EU/µg protein (determined by LAL method).
75 kDa
50 µg/$707
FGFR1 / FGF Receptor 1 Rabbit anti-Human Polyclonal (600-680 aa) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FGFR1 / FGF Receptor 1 Mouse anti-Human Monoclonal (aa22-376) (GF1) Antibody
Human
ELISA
Unconjugated
100 µl/$688
FGFR1 / FGF Receptor 1 Rabbit anti-Human Polyclonal (pTyr654) Antibody
Chicken, Zebrafish, Pig, Rat, Rabbit, Mouse, Human
WB
Unconjugated
100 µl/$315
FGFR1 / FGF Receptor 1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$371
FGFR1 / FGF Receptor 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
Flo, IF, IP, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
HEK 293 Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
31 kDa
100 µg/$721
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of 247
product results
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