FGFR1 / FGF Receptor 1

fibroblast growth factor receptor 1

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

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Products

ELISA Kits (21)

Type

Cell-Based (1)

Cell-Based Phosphorylation (3)

Custom (3)

Sandwich (13)

Sandwich CLIA (1)

Target

FGFR1 / FGF Receptor 1 (21)

Reactivity

Human (9)

Mouse (7)

Rat (8)

Chicken (2)

Monkey (1)

Porcine (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (7)

96-Well Strip Plate (13)

Publications

No (20)

Yes (1)

Sample Type

Adherent Cell Cultures (4)

Cell Lysates (2)

Plasma (7)

Serum (6)

Tissue Homogenates (5)

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Human FGFR1 / FGF Receptor 1 (Sandwich ELISA) ELISA Kit - LS-F11464

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse/Human/Rat Phospho-FGFR1 / FGF Receptor 1 (Tyr654) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1170

(4.0) Rating

(1) Publication(s)

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human FGFR1 / FGF Receptor 1 (Sandwich ELISA) ELISA Kit - LS-F20894

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse FGFR1 / FGF Receptor 1 (Sandwich ELISA) ELISA Kit - LS-F6175

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$818

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Chicken FGFR1 / FGF Receptor 1 (Sandwich ELISA) ELISA Kit - LS-F43927

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Monkey FGFR1 / FGF Receptor 1 (Sandwich ELISA) ELISA Kit - LS-F43929

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Porcine FGFR1 / FGF Receptor 1 (Sandwich ELISA) ELISA Kit - LS-F43930

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Rabbit FGFR1 / FGF Receptor 1 (Sandwich ELISA) ELISA Kit - LS-F43933

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Rat FGFR1 / FGF Receptor 1 (Custom ELISA) ELISA Kit - LS-F13685

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Mouse FGFR1 / FGF Receptor 1 (Custom ELISA) ELISA Kit - LS-F13686

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Chicken FGFR1 / FGF Receptor 1 (Custom ELISA) ELISA Kit - LS-F13687

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

Select

Human FGFR1 / FGF Receptor 1 (CLIA) ELISA Kit - LS-F29308

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Rat FGFR1 / FGF Receptor 1 (Sandwich ELISA) ELISA Kit - LS-F21651

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Mouse FGFR1 / FGF Receptor 1 (Sandwich ELISA) ELISA Kit - LS-F21474

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human FGFR1 / FGF Receptor 1 (Sandwich ELISA) ELISA Kit - LS-F34478

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat FGFR1 / FGF Receptor 1 (Sandwich ELISA) ELISA Kit - LS-F34479

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human FGFR1 / FGF Receptor 1 (Sandwich ELISA) ELISA Kit - LS-F6069

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

Select

Rat FGFR1 / FGF Receptor 1 (Sandwich ELISA) ELISA Kit - LS-F8692

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$856

Select

Mouse/Human/Rat Phospho-FGFR1 / FGF Receptor 1 (Tyr154) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1509

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Mouse/Human/Rat FGFR1 / FGF Receptor 1 (Cell-Based ELISA) ELISA Kit - LS-F1987

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

Select

Mouse/Human/Rat Phospho-FGFR1 / FGF Receptor 1 (Tyr766) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1169

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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