FGFR1 / FGF Receptor 1

fibroblast growth factor receptor 1

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

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Products

Proteins (26)

Type

Over-Expression Lysate (10)

Recombinant (16)

Target

FGFR1 / FGF Receptor 1 (26)

Publications

No (26)

Tag

6His, N-terminus (1)

6His-SUMOstar, N-terminus (1)

Fc (1)

GST (1)

GST, N-terminus (2)

His (2)

His,C-terminus (1)

His,N-terminus + GST (1)

His-T7 (1)

Mouse IgG2a Fc, N-terminus (1)

Myc-DDK (Flag) (14)

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Species

Human (17)

Mouse (3)

Rat (1)

Source

293T Cells (5)

E. coli (3)

HEK 293 Cells (12)

Human Cells (1)

Insect Cells (1)

Wheat Germ Extract (3)

Yeast (1)

Purification

Purified (8)

Low Endotoxin Level

Low endotoxin level (5)

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Human FGFR1 / FGF Receptor 1 Protein (Recombinant His,N-terminus + GST) (Gly311-Arg731) - LS-G140006

Source:

Insect Cells

Tag:

His,N-terminus + GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

75 kDa

Price:

50 µg/$707

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Human FGFR1 / FGF Receptor 1 Protein (Recombinant His) (Met1-Glu285) - LS-G98579

Source:

HEK 293 Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

31 kDa

Price:

100 µg/$721

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Human FGFR1 / FGF Receptor 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74704

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

91.38 kDa

Price:

20 µg/$215

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Human FGFR1 / FGF Receptor 1 Protein (Recombinant 6His-SUMOstar, N-terminus) - LS-G136585

Source:

Yeast

Tag:

6His-SUMOstar, N-terminus

Molecular Weight:

55.4 kDa

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human FGFR1 / FGF Receptor 1 Protein (Recombinant 6His, N-terminus) - LS-G137018

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

43.4 kDa

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Mouse FGFR1 / FGF Receptor 1 Protein (Recombinant Mouse IgG2a Fc, N-terminus) - LS-G134257

Source:

HEK 293 Cells

Tag:

Mouse IgG2a Fc, N-terminus

Endotoxin Level:

Less than 5.0 EU/mg protein (determined by LAL method).

Molecular Weight:

~110 kDa (SDS-PAGE)

Price:

100 µg/$463

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Mouse FGFR1 / FGF Receptor 1 Protein (Recombinant His,C-terminus) (Met1-Glu376) - LS-G138327

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

40.9 kDa

Price:

100 µg/$843

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FGFR1 / FGF Receptor 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110206

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.6 kDa

Price:

100 µg/$494

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FGFR1 / FGF Receptor 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110203

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.4 kDa

Price:

100 µg/$710

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FGFR1 / FGF Receptor 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110205

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.9 kDa

Price:

100 µg/$494

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FGFR1 / FGF Receptor 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113047

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

91.38 kDa

Price:

100 µg/$710

Select

Human FGFR1 / FGF Receptor 1 Protein (Recombinant GST) (Full Length) - LS-G28467

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

108.3 kDa

Price:

2 µg/$439

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Rat FGFR1 / FGF Receptor 1 Protein (Recombinant His-T7) (aa22-376) - LS-G24493

Source:

E. coli

Tag:

His-T7

Molecular Weight:

43.2 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human FGFR1 / FGF Receptor 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74705

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.4 kDa

Price:

20 µg/$215

Select

Human FGFR1 / FGF Receptor 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74707

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.9 kDa

Price:

20 µg/$150

Select

Human FGFR1 / FGF Receptor 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74711

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.4 kDa

Price:

20 µg/$150

Select

Human FGFR1 / FGF Receptor 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74710

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.6 kDa

Price:

20 µg/$150

Select

Human FGFR1 / FGF Receptor 1 Protein (Recombinant GST, N-terminus) (aa31-150) - LS-G58560

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human FGFR1 / FGF Receptor 1 Protein (Recombinant GST, N-terminus) (aa303-408) - LS-G58562

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human FGFR1 / FGF Receptor 1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65039

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.4 kDa

Price:

20 µg/$1,107

Select

Human FGFR1 / FGF Receptor 1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65041

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.9 kDa

Price:

20 µg/$1,107

Select

Human FGFR1 / FGF Receptor 1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65040

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.4 kDa

Price:

20 µg/$1,107

Select

Human FGFR1 / FGF Receptor 1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65042

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.6 kDa

Price:

20 µg/$1,107

Select

Mouse FGFR1 / FGF Receptor 1 Protein (Recombinant Fc) (Met1-Glu376) - LS-G98778

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

66.5 kDa

Price:

100 µg/$843

Select

FGFR1 / FGF Receptor 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101847

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.4 kDa

Price:

100 µg/$494

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