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FGF2 / Basic FGF
fibroblast growth factor 2 (basic)
FGF2 / Basic FGF is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
| Gene Name: | fibroblast growth factor 2 (basic) |
| Family/Subfamily: | HBGF , not assigned-HBGF |
| Synonyms: | FGF2, Basic fibroblast growth factor, FGFB, Fibroblast growth factor 2, FGF-2, Prostatropin, BFGF, HBGF-2 |
| Target Sequences: | NM_002006 NP_001997.5 P09038 |
Publications (1)
1
A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma10<sup> Washington University School of Medicine, St. Louis, MO, USA12<sup> Memorial Sloan Kettering Cancer Center, New York, NY, USA14<sup> GlaxoSmithKline, Inc., 1250 South Collegeville Road, Collegeville, PA, USA16<sup> Utrecht University, Utrecht, The Netherlands18<sup> Phase I Trials Unit, Medical Oncology Department, Hospital Universitario Virgen de. Emilie M J van Brummelen, Evgeny Levchenko, Manuel Dómine, Dean A Fennell, Hedy L Kindler, Santiago Viteri, Shirish Gadgeel, Pilar Garrido López, Vladimir Kostorov, Daniel Morgensztern, Sergey Orlov, Marjorie G Zauderer, Johan F Vansteenkiste, Katherine Baker-Neblett, James Vasquez, Xiaowei Wang, David I Bellovin, Jan H M Schellens, Li Yan, Ionel Mitrica, M Phillip DeYoung, José Trigo. Investigational new drugs. 2020 Apr;;38:457-467. [Full Text Article]
[PubMed:31065954]
[PMC:PMC6898757]
Related Antibodies: LS-B10042.
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FGF2 / Basic FGF
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Neuroscience
FGF2 / Basic FGF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Neuroscience
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (aa 143-288) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
FGF2 / Basic FGF Mouse anti-Bovine Monoclonal Antibody
Mouse, Bovine, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$463; 500 µg/$925
FGF2 / Basic FGF Rabbit anti-Bovine Polyclonal Antibody
Bovine, Pig, Human
IHC, RIA, WB
Unconjugated
20 µl/$488; 100 µl/$957
FGF2 / Basic FGF Rabbit anti-Mouse Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (aa219-249) Antibody
Rat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
FGF2 / Basic FGF Mouse anti-Human Monoclonal (OTI3D10) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
FGF2 / Basic FGF Mouse anti-Human Monoclonal (2H5G2C11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 ml/$380
FGF2 / Basic FGF Mouse anti-Bovine Monoclonal Antibody
Bovine, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
500 µg/$1,042
FGF2 / Basic FGF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Neut, WB
Unconjugated
50 µg/$494
FGF2 / Basic FGF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
FGF2 / Basic FGF Rabbit anti-Mouse Polyclonal (aa10-154) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
FGF2 / Basic FGF Rabbit anti-Human Monoclonal (Preservative Free) (101) Antibody
Human
ELISA
Unconjugated, Preservative Free
100 µl/$412
FGF2 / Basic FGF Mouse anti-Bovine Monoclonal Antibody
Mouse, Bovine, Rat, Human
Neut
Unconjugated
500 µg/$866
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (aa163-191) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (aa163-191) (Biotin) Antibody
Human
ELISA, IF, IHC, WB
Biotin Conjugated
200 µl/$952
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (aa163-191) (APC) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (aa163-191) (PE) Antibody
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
FGF2 / Basic FGF Mouse anti-Human Monoclonal (aa10-155) (Carrier-free) (3D9) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
FGF2 / Basic FGF Mouse anti-Human Monoclonal (OTI2H11) Antibody
Human
ICC, IF, WB
Unconjugated
100 µl/$434
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (aa143-288) Antibody
Human
ELISA, IHC, IHC-P, IP, Neut, WB
Unconjugated
10 µg/$318; 100 µg/$470
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (aa143-288) Antibody
Human
ELISA, Func, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$575
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product results
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