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FFAR1 / GPR40

free fatty acid receptor 1

G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.

Gene Name: free fatty acid receptor 1
Family/Subfamily: GPCR , Carboxylic Acid
Synonyms: FFAR1, FFAR, FFA1R, G protein-coupled receptor 40, GPCR40, GPR40, Free fatty acid receptor, Free fatty acid receptor 1, G-protein coupled receptor 40
Target Sequences: NM_005303 NP_005294.1 O14842

Publications (1)

1
Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion. Kristinsson H, Sargsyan E, Manell H, Smith DM, Göpel SO, Bergsten P. Scientific reports. 2017 July;7:4657. [Full Text Article] [PubMed:28680093] [PMC:PMC5498543]

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Products
Antibodies (23)
Primary (23)
FFAR1 / GPR40 (23)
Human (22)
Mouse (2)
Rat (2)
Monkey (3)
IHC (5)
IHC-P (4)
WB (17)
ELISA (8)
IF (4)
Peptide-ELISA (3)
rabbit (22)
goat (1)
Product Group
GPCR Database Antibodies (2)
IHCPlus (1)
PathPlus Neuro (2)
IgG (16)
polyclonal pc (23)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (15)
aa275-300 (7)
160-240 aa, Internal (1)
C-Terminus (1)
Cytoplasmic Domain (1)
Internal (1)
aa185-234 (1)
aa289-300 (1)
No (23)
FFAR1 / GPR40 Antibody - Anti-FFAR1 / GPR40 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$440
FFAR1 / GPR40 Antibody - Anti-GPR40 antibody IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
IHC, IHC-P
Unconjugated
50 µg/$440
FFAR1 / GPR40 Antibody - Anti-GPR40 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
FFAR1 / GPR40 Antibody - Immunofluorescence analysis of LOVO cells, using FFAR1 Antibody. The picture on the right is blocked with the synthesized peptide.
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (aa185-234) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
FFAR1 / GPR40 Antibody - Western blot analysis of GPR40 expression in K562 (A); mouse kidney (B); COS7 (C) whole cell lysates.
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
FFAR1 / GPR40 Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
FFAR1 / GPR40 Antibody - Western blot of GPR40 antibody
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (160-240 aa, Internal) Antibody
Human, Monkey
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FFAR1 / GPR40 Antibody - Peptide - + Immunofluorescence analysis of LOVO cells, using FFAR1antibody.
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$357
FFAR1 / GPR40 Antibody - Western blot analysis FFAR1 using K562 whole cells lysates
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal Antibody
Human
IHC
Unconjugated
1 Each/$431
FFAR1 / GPR40 Antibody - Antibody (0.01 ug/ml) staining of Human Breast lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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FFAR1 / GPR40 Goat anti-Human Polyclonal (aa289-300) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (aa275-300) Antibody
Human
WB
Unconjugated
200 µl/$734
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (aa275-300) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (aa275-300) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (aa275-300) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (aa275-300) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (aa275-300) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
FFAR1 / GPR40 Antibody - FFAR1 Antibody western blot of CEM cell line lysates (35 ug/lane). The FFAR1 antibody detected the FFAR1 protein (arrow).
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal (aa275-300) Antibody
Human
WB
Unconjugated
400 µl/$393
FFAR1 / GPR40 Antibody - Western blot - Anti-GPCR GPR40 Picoband antibody
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
FFAR1 / GPR40 Antibody - Western blot testing of human PANC-1 cell lysate with GPR40 antibody at 0.5ug/ml. Predicted molecular weight ~31 kDa.
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FFAR1 / GPR40 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$575
Viewing 1-23 of 23 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).