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FECH / Ferrochelatase

ferrochelatase

FECH / Ferrochelatase is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.

Gene Name: ferrochelatase
Synonyms: FECH, FCE, Heme synthase, EPP, Heme synthetase, Protoheme ferro-lyase, Protoporphyria, Ferrochelatase, Ferrochelatase, mitochondrial
Target Sequences: NM_000140 NP_000131.2 P22830

Publications (2)

1
Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy. Teng L, Nakada M, Zhao SG, Endo Y, Furuyama N, Nambu E, Pyko IV, Hayashi Y, Hamada JI. British journal of cancer. 2011 104:798-807. (WB; Human) [Full Text Article] [PubMed:21304523] Related Antibodies: LS-C307514.
2
Ferrochelatase regulates retinal neovascularization. Sardar Pasha Sheik Pran Babu, Darcy White, Timothy W Corson. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 September;34:12419-12435. [Full Text Article] [PubMed:32716567] [PMC:PMC7726024 (ava] Related Antibodies: LS-C409953.

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Proteins (9)
Over-Expression Lysate (4)
Recombinant (5)
FECH / Ferrochelatase (9)
No (9)
GST (1)
GST, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (6)
Human (7)
293T Cells (2)
E. coli (1)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (1)
FECH / Ferrochelatase Protein - Recombinant  Ferrochelatase By SDS-PAGE
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E. coli
His-T7
45.9 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
FECH / Ferrochelatase Protein - Purified recombinant protein FECH was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
42.1 kDa
20 µg/$1,107
FECH / Ferrochelatase Protein - Purified recombinant protein FECH was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
42.9 kDa
20 µg/$1,107
FECH / Ferrochelatase Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
FECH / Ferrochelatase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
47.86 kDa
20 µg/$150
FECH / Ferrochelatase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
48.63 kDa
20 µg/$215
FECH / Ferrochelatase Protein - 12.5% SDS-PAGE of human FECH stained with Coomassie Blue
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Wheat Germ Extract
GST
72.16 kDa
2 µg/$439
FECH / Ferrochelatase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
47.86 kDa
100 µg/$494
FECH / Ferrochelatase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
48.63 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).