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FCGR3A / CD16A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

FCGR3A / CD16A is a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Synonyms: FCGR3A, CD16A, CD16a antigen, CD16, FcgammaRIIIA, FCR-10, FCRIII, Fc gamma receptor III-A, Fc-gamma RIII, Fc-gamma RIII-alpha, FCG3, IGFR3, Fc- gamma riii, Fc-gamma receptor IIIb (CD16), Fc-gamma RIIIa, FCGR3, FCRIIIA, Neutrophil-specific antigen NA, Igg fc receptor iii-1, IgG Fc receptor III-2, Igg fc receptors iii-1, FCGRIII
Target Sequences: NM_000569 NP_000560.5 P08637

Publications (1)

1
In Vitro Exposure to Prostratin but Not Bryostatin-1 Improves Natural Killer Cell Functions Including Killing of CD4+ T Cells Harboring Reactivated Human Immunodeficiency Virus. Desimio MG, Giuliani E, Ferraro AS, Adorno G, Doria M. Frontiers in immunology. 2018 June;9: [Full Text Article] [PubMed:30008723] [PMC:PMC6033996]

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Products
Proteins (31)
Over-Expression Lysate (6)
Recombinant (25)
FCGR3A / CD16A (31)
No (31)
6His, C-terminus (9)
AVI + HisC-terminus (1)
GST (1)
His (5)
His,C-terminus (1)
His-AVI (5)
His-GST (2)
Myc-DDK (Flag) (7)
Cynomolgus (1)
Human (19)
Mouse (6)
Rat (2)
293T Cells (3)
CHO Cells (2)
E. coli (3)
HEK 293 Cells (6)
Human (1)
Human Cells (12)
Mammalian Cells (3)
Wheat Germ Extract (1)
Purified (8)
Low endotoxin level (20)
Biologically active (1)
Select
CHO Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.3 kDa
100 µg/$721; 1 mg/$4,701
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22.61kD
10 µg/$269; 50 µg/$372; 500 µg/$1,585; 1 mg/$2,157
FCGR3A / CD16A Protein - 12.5% SDS-PAGE of human FCGR3A stained with Coomassie Blue
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Wheat Germ Extract
GST
51.92 kDa
10 µg/$479; 25 µg/$670
FCGR3A / CD16A Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
FCGR3A / CD16A Protein - Recombinant Fc Fragment Of IgG Low Affinity IIIa Receptor By SDS-PAGE
Select
E. coli
His-GST
58.7 kDa
10 µg/$280; 50 µg/$435; 100 µg/$695; 200 µg/$870; 1 mg/$1,972; 500 µg/$1,514; 5 mg/$3,039; 2 mg/$2,159
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
21.7 kDa
100 µg/$843
FCGR3A / CD16A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
32.64 kDa
100 µg/$494
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22.7kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.9kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
FCGR3A / CD16A Protein - Purified recombinant protein FCGR3A was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
27.2 kDa
20 µg/$1,107
Select
293T Cells
Myc-DDK (Flag)
29.4 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
29.09 kDa
20 µg/$150
FCGR3A / CD16A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
32.64 kDa
20 µg/$150
FCGR3A / CD16A Protein - Recombinant Fc Fragment Of IgG Low Affinity IIIa Receptor By SDS-PAGE
Select
E. coli
His-GST
58.3 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
FCGR3A / CD16A Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
22.61 kDa
50 µg/$424; 10 µg/$288; 1 mg/$2,837; 500 µg/$1,987
Select
HEK 293 Cells
AVI + HisC-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.1 kDa
100 µg/$843; 1 mg/$5,493
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22.6 kDa
10 µg/$269; 50 µg/$368
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22.4 kDa
100 µg/$721; 1 mg/$4,701
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22.7 kDa
10 µg/$281; 50 µg/$389
Select
HEK 293 Cells
Myc-DDK (Flag)
29.09 kDa
100 µg/$494
Select
HEK 293 Cells
Myc-DDK (Flag)
29.4 kDa
100 µg/$494
FCGR3A / CD16A Protein - Recombinant Cynomolgus Fc gamma RIIIA/FCGR3A/CD16a (C-6His)
Select
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22 kDa
10 µg/$335; 50 µg/$615
Select
Human Cells
His-AVI
Less than 1.0 EU/µg protein (determined by LAL method).
24.2 kDa
20 µg/$725; 100 µg/$1,467
Select
Human Cells
His-AVI
Less than 1.0 EU/µg protein (determined by LAL method).
24.2 kDa
100 µg/$721; 1 mg/$4,701
Viewing 1-25 of 31 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).