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Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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Additional Contact Details
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FCGR3A / CD16A
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3A / CD16A is a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) |
| Synonyms: | FCGR3A, CD16A, CD16a antigen, CD16, FcgammaRIIIA, FCR-10, FCRIII, Fc gamma receptor III-A, Fc-gamma RIII, Fc-gamma RIII-alpha, FCG3, IGFR3, Fc- gamma riii, Fc-gamma receptor IIIb (CD16), Fc-gamma RIIIa, FCGR3, FCRIIIA, Neutrophil-specific antigen NA, Igg fc receptor iii-1, IgG Fc receptor III-2, Igg fc receptors iii-1, FCGRIII |
| Target Sequences: | NM_000569 NP_000560.5 P08637 |
Publications (1)
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