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FCGR2 / CD32

CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling. It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loop acts to lower the production of IgG by B cells when there is a surplus in the body. Monoclonal antibodies can distinguish between CD32A and CD32B.

FCGR2 / CD32 Target Details

Target Name: FCGR2 / CD32

Publications (3)

1
C-reactive protein and annexin A5 bind to distinct sites of negatively charged phospholipids present in oxidized low-density lipoprotein. van Tits L, de Graaf J, Toenhake H, van Heerde W, Stalenhoef A. Arteriosclerosis, thrombosis, and vascular biology. 2005 25:717-22. [PubMed:15692104] Related Antibodies: LS-C41118.
2
Toll-like receptor 2 mediates the activation of human monocytes and endothelial cells by antiphospholipid antibodies. Satta N, Kruithof EK, Fickentscher C, Dunoyer-Geindre S, Boehlen F, Reber G, Burger D, de Moerloose P. Blood. 2011 117:5523-31. [PubMed:21330474] Related Antibodies: LS-C41118.
3
Factor H-IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen Streptococcus pyogenes. Blom AM, Magda M, Kohl L, Shaughnessy J, Lambris JD, Ram S, Ermert D. Journal of immunology (Baltimore, Md. : 1950). 2017 December;199:3828-3839. [Full Text Article] [PubMed:29084837] [PMC:PMC5698128] Related Antibodies: LS-C187457.

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Proteins (2)
Recombinant (2)
FCGR2 / CD32 (2)
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6His, C-terminus (1)
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Mouse (1)
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E. coli (1)
Human Cells (1)
Low endotoxin level (1)
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.6kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
FCGR2 / CD32 Protein - Recombinant Receptor II For The Fc Region Of Immunoglobulin G By SDS-PAGE
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E. coli
His-T7
30.7 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).