FBXW8

F-box and WD repeat domain containing 8

Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).

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Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

FBXW8 (6)

Publications

No (6)

Tag

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (4)

Species

Human (4)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human FBXW8 Protein (Recombinant GST, N-terminus) (aa499-598) - LS-G62165

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human FBXW8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G94090

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.5 kDa

Price:

20 µg/$215

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Human FBXW8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G94091

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.2 kDa

Price:

20 µg/$150

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FBXW8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105795

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.2 kDa

Price:

100 µg/$494

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Human FBXW8 Protein (Recombinant His, N-Terminal) - LS-G145112

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

67.2 kDa

Price:

50 µg/$419

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FBXW8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114615

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.5 kDa

Price:

100 µg/$710

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