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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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FBXW7 / FBW7

F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase

FBXW7 / FBW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Family/Subfamily: F-Box
Synonyms: FBXW7, AGO, Archipelago homolog, Archipelago, CDC4, F-box protein FBW7, FBXW6, F-box protein FBX30, F-box protein SEL-10, HCdc4, Homolog of C elegans sel-10, FBW6, FBX30, FBW7, HAgo, SEL-10, SEL10
Target Sequences: NM_018315 NP_060785.2 Q969H0

Filtered by: None
Target
FBXW7 / FBW7 (82)
Reactivity
Human (70)
Mouse (22)
Rat (11)
Bat (4)
Bovine (4)
Chicken (4)
Chimpanzee (3)
Dog (4)
Drosophila (4)
Gibbon (3)
Guinea pig (4)
Hamster (8)
Horse (4)
Monkey (5)
Orangutan (3)
Pig (4)
Rabbit (4)
Xenopus (4)
Zebrafish (4)
Application
IHC (30)
IHC-P (17)
WB (73)
ELISA (11)
ICC (1)
IF (1)
IP (9)
Peptide-ELISA (2)
Host
rabbit (60)
mouse (22)
Isotype
IgG (35)
IgG1 (4)
IgG2a (8)
IgG2a,k (1)
IgG2b (8)
Clonality
monoclonal mc (21)
polyclonal pc (61)
Clone
13H4 (2)
3D1 (1)
OTI10B9 (2)
OTI1C7 (2)
OTI2E12 (2)
OTI2G7 (2)
OTI4C11 (2)
OTI4E7 (2)
OTI6B1 (2)
OTI6F5 (2)
OTI6H1 (2)
Format
AP Conjugated (2)
APC (2)
APC Conjugated (4)
Biotin Conjugated (7)
Carrier-free (10)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (7)
HRP Conjugated (7)
PE Conjugated (4)
Unconjugated (47)
Epitope
aa1-354 (20)
aa279-515 (8)
aa312-545 (8)
C-Terminus (4)
aa251-300 (4)
N-Terminus (3)
aa50-100 (2)
Internal (1)
aa1-50 (1)
aa133-167 (1)
aa177-208 (1)
Publications
No (82)
Showing 1-25 of 82 results

IHC-plus™ FBXW7 / FBW7 Antibody (clone 3D1) LS-B6352
Mouse Monoclonal [clone 3D1] (IgG2a,k) to Human FBXW7 / FBW7
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg  $495.00
Anti-FBXW7 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Detection limit for recombinant GST tagged FBXW7 is approximately 0.1 ng/ml as a capture antibody.

IHC-plus™ FBXW7 / FBW7 Antibody (Internal) LS-B2909
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Human
IHC, IHC-P, IP, WB
Unconjugated
50µg 0.25mg/ml  $485.00
Anti-FBXW7 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

IHC-plus™ FBXW7 / FBW7 Antibody (aa251-300) LS-B5634
Rabbit Polyclonal to Mouse FBXW7 / FBW7
Mouse, Rat, Hamster
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-FBXW7 antibody IHC of mouse brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
FBXW7 antibody Western blot of Mouse Lung lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

FBXW7 / FBW7 Antibody (aa251-300, HRP) LS-C435570
Rabbit Polyclonal to Mouse FBXW7 / FBW7
Mouse, Rat, Hamster
IHC, IHC-P, WB
HRP Conjugated
100µl 0.65mg/ml  $405.00
Anti-FBXW7 antibody IHC of mouse brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
FBXW7 antibody Western blot of Mouse Lung lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

FBXW7 / FBW7 Antibody (aa251-300, Biotin) LS-C435567
Rabbit Polyclonal to Mouse FBXW7 / FBW7
Mouse, Rat, Hamster
IHC, IHC-P, WB
Biotin Conjugated
100µl 1mg/ml  $405.00
Anti-FBXW7 antibody IHC of mouse brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
FBXW7 antibody Western blot of Mouse Lung lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

FBXW7 / FBW7 Antibody (aa251-300, FITC) LS-C435568
Rabbit Polyclonal to Mouse FBXW7 / FBW7
Mouse, Rat, Hamster
IHC, IHC-P, WB
FITC Conjugated
100µl 1mg/ml  $405.00
Anti-FBXW7 antibody IHC of mouse brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
FBXW7 antibody Western blot of Mouse Lung lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ FBXW7 / FBW7 Antibody (C-Terminus) LS-B5800
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Xenopus, Chicken, Zebrafish, Drosophila, Pig, Horse, Bat, Rat, Hamster, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-FBXW7 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Jurkat cell lysate. Antibody concentration: 0.25 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ FBXW7 / FBW7 Antibody (N-Terminus) LS-B4758
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-FBXW7 antibody IHC of human: brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-FBXW7 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

FBXW7 / FBW7 Antibody (aa1-354, clone OTI1C7) LS-C338611
Mouse Monoclonal [clone OTI1C7] (IgG1) to Human FBXW7 / FBW7
Human
WB
Unconjugated
100µl 1mg/ml  $345.00
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FBXW7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FBXW7.

FBXW7 / FBW7 Antibody (aa1-354, clone OTI6F5) LS-C336716
Mouse Monoclonal [clone OTI6F5] (IgG2a) to Human FBXW7 / FBW7
Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
IHC of paraffin-embedded Human colon tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

FBXW7 / FBW7 Antibody (aa1-354, clone OTI6F5, Carrier-free) LS-C789680
Mouse Monoclonal [clone OTI6F5] (IgG2a) to Human FBXW7 / FBW7
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00

IHC-plus™ FBXW7 / FBW7 Antibody (aa1-354, clone 13H4) LS-B16413
Mouse Monoclonal [clone 13H4] (IgG2b) to Human FBXW7 / FBW7
Human
IHC-P, WB
Unconjugated
50µl  $425.00
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

FBXW7 / FBW7 Antibody LS-C348967
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Mouse, Rat, Human
IHC, WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded mouse lung tissue.
Immunohistochemistry of paraffin-embedded mouse kidney tissue.

FBXW7 / FBW7 Antibody (aa1-354, clone OTI2G7) LS-C336704
Mouse Monoclonal [clone OTI2G7] (IgG2a) to Human FBXW7 / FBW7
Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Human colon tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
IHC of paraffin-embedded Human pancreas tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

FBXW7 / FBW7 Antibody (aa1-354, clone OTI2G7, Carrier-free) LS-C789662
Mouse Monoclonal [clone OTI2G7] (IgG2a) to Human FBXW7 / FBW7
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00

FBXW7 / FBW7 Antibody LS-C677916
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Human
ELISA, ICC, IHC
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry analysis of human kidney tissue at a dilution of 1:100
Immunocytochemistry analysis of human small intestine tissue diluted at 1:100

FBXW7 / FBW7 Antibody LS-C802892
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00

FBXW7 / FBW7 Antibody LS-C751989
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Human
ELISA, IHC, WB
Unconjugated
100µg  $375.00

FBXW7 / FBW7 Antibody (aa1-354, clone OTI10B9) LS-C338610
Mouse Monoclonal [clone OTI10B9] (IgG2a) to Human FBXW7 / FBW7
Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Human bladder tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FBXW7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FBXW7.

FBXW7 / FBW7 Antibody (aa1-354, clone OTI10B9, Carrier-free) LS-C789682
Mouse Monoclonal [clone OTI10B9] (IgG2a) to Human FBXW7 / FBW7
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00

FBXW7 / FBW7 Antibody (aa1-354, clone OTI4C11) LS-C336721
Mouse Monoclonal [clone OTI4C11] (IgG2b) to Human FBXW7 / FBW7
Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FBXW7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FBXW7.

FBXW7 / FBW7 Antibody (aa1-354, clone OTI4C11, Carrier-free) LS-C789686
Mouse Monoclonal [clone OTI4C11] (IgG2b) to Human FBXW7 / FBW7
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00

FBXW7 / FBW7 Antibody (aa1-354, clone 13H4, Carrier-free) LS-C789722
Mouse Monoclonal [clone 13H4] (IgG2b) to Human FBXW7 / FBW7
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00

FBXW7 / FBW7 Antibody LS-C668795
Rabbit Polyclonal to Human FBXW7 / FBW7
Human
IHC, IHC-P, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $275.00
Immunohistochemistry - Paraffin Image
Western blot Image

FBXW7 / FBW7 Antibody LS-C766552
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Mouse, Rat, Human
IHC, WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00
Showing 1-25 of 82 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).