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FBXW2
F-box and WD repeat domain containing 2
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
| Gene Name: | F-box and WD repeat domain containing 2 |
| Family/Subfamily: | F-Box |
| Synonyms: | FBXW2, FBW2, Protein MD6, Md6, Fwd2 |
| Target Sequences: | NM_012164 NP_036296.2 Q9UKT8 |
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