FBXW11

F-box and WD repeat domain containing 11

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.

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Proteins (8)

Type

Over-Expression Lysate (6)

Recombinant (2)

Target

FBXW11 (8)

Publications

No (8)

Tag

GST (1)

Myc-DDK (Flag) (7)

Species

Human (5)

Source

293T Cells (3)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human FBXW11 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70306

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.7 kDa

Price:

20 µg/$1,107

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Human FBXW11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86741

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.7 kDa

Price:

20 µg/$150

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Human FBXW11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86742

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.9 kDa

Price:

20 µg/$215

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Human FBXW11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86743

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.2 kDa

Price:

20 µg/$215

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Human FBXW11 Protein (Recombinant GST) (Full Length) - LS-G32787

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

83.93 kDa

Price:

10 µg/$479; 25 µg/$670

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FBXW11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108181

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.7 kDa

Price:

100 µg/$494

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FBXW11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108182

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.2 kDa

Price:

100 µg/$710

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FBXW11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114526

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.9 kDa

Price:

100 µg/$710

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