FBXO32 / Fbx32 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
|Gene Name:||F-box protein 32|
|Synonyms:||FBXO32, Atrogin 1, ATROGIN1, F-box protein 32, F-box only protein 32, Fbx32, Muscle atrophy F-box protein, MAFBX, Atrogin-1|
|Target Sequences:||NM_058229 NP_478136.1 Q969P5|
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