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FBXO32 / Fbx32

F-box protein 32

FBXO32 / Fbx32 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: F-box protein 32
Family/Subfamily: F-Box
Synonyms: FBXO32, Atrogin 1, ATROGIN1, F-box protein 32, F-box only protein 32, Fbx32, Muscle atrophy F-box protein, MAFBX, Atrogin-1
Target Sequences: NM_058229 NP_478136.1 Q969P5

Publications (1)

1
FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation. Zhou H, Liu Y, Zhu R, Ding F, Wan Y, Li Y, Liu Z. Oncogene. 2017 June;36:3312-3321. (Human) [Full Text Article] [PubMed:28068319] [PMC:PMC5926769] Related Antibodies: LS-B9748.

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Proteins (9)
Over-Expression Lysate (6)
Recombinant (3)
FBXO32 / Fbx32 (9)
No (9)
GST (1)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (6)
Human (6)
293T Cells (3)
E. coli (2)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (1)
FBXO32 / Fbx32 Protein - Recombinant  F-Box Protein 32 By SDS-PAGE
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E. coli
His-T7
27.2 kDa
10 µg/$273; 50 µg/$429; 100 µg/$686; 200 µg/$855; 1 mg/$1,906
FBXO32 / Fbx32 Protein
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E. coli
His, N-Terminal
24.5 kDa
50 µg/$390
FBXO32 / Fbx32 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
24.5 kDa
100 µg/$458
FBXO32 / Fbx32 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
41.5 kDa
100 µg/$412
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293T Cells
Myc-DDK (Flag)
41.5 kDa
20 µg/$110
FBXO32 / Fbx32 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
24.5 kDa
20 µg/$130
FBXO32 / Fbx32 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
41.5 kDa
20 µg/$130
FBXO32 / Fbx32 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
41.5 kDa
100 µg/$458
FBXO32 / Fbx32 Protein - 12.5% SDS-PAGE of human FBXO32 stained with Coomassie Blue
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Wheat Germ Extract
GST
48.84 kDa
2 µg/$421
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).