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FBXO22
F-box protein 22
FBXO22 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants.
| Gene Name: | F-box protein 22 |
| Family/Subfamily: | F-Box |
| Synonyms: | FBXO22, FBX22, FISTC1, F-box protein FBX22p44, F-box protein 22, FIST domain containing 1, F-box only protein 22 |
| Target Sequences: | NM_012170 NP_036302.1 Q8NEZ5 |
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