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FBXO18 / FBH1
F-box protein, helicase, 18
FBXO18 / FBH1 is a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
| Gene Name: | F-box protein, helicase, 18 |
| Family/Subfamily: | F-Box |
| Synonyms: | FBXO18, F-box DNA helicase 1, F-box only protein 18, F-box protein, helicase, 18, FBH1, Fbx18 |
| Target Sequences: | NM_032807 NP_116196.3 Q8NFZ0 |
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