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FBXL4 / FBL5
F-box and leucine-rich repeat protein 4
FBXL4 / FBL5 encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants.
| Gene Name: | F-box and leucine-rich repeat protein 4 |
| Family/Subfamily: | F-Box |
| Synonyms: | FBXL4, F-box protein FBL4, F-box/LRR-repeat protein 4, FBL5, FBL4 |
| Target Sequences: | NM_012160 NP_036292.2 Q9UKA2 |
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