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FBXL2

F-box and leucine-rich repeat protein 2

Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation may induce cell-cycle arrest in G0. SCF(FBXL2) may also mediate PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and indirectly autophagy (PubMed:22323446, PubMed:22020328, PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation may regulate synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant.

Gene Name: F-box and leucine-rich repeat protein 2
Family/Subfamily: F-Box
Synonyms: FBXL2, F-box/LRR-repeat protein 2, F-box protein FBL2/FBL3, FBL3, Fbl2
Target Sequences: NM_012157

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Products
Proteins (8)
Over-Expression Lysate (4)
Recombinant (4)
FBXL2 (8)
No (8)
6His, N-terminus (1)
GST (1)
His-SUMO (1)
Myc-DDK (Flag) (5)
Human (6)
293T Cells (2)
E. coli (1)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Yeast (1)
Purified (2)
FBXL2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
1 mg/$1,607; 100 µg/$469; 20 µg/$349
FBXL2 Protein - Purified recombinant protein FBXL2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
46.9 kDa
20 µg/$1,107
FBXL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
46.9 kDa
20 µg/$150
FBXL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
40.1 kDa
20 µg/$150
FBXL2 Protein
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E. coli
His-SUMO
63.03 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
FBXL2 Protein - 12.5% SDS-PAGE of human FBXL2 stained with Coomassie Blue
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Wheat Germ Extract
GST
72.38 kDa
10 µg/$479; 25 µg/$670
FBXL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
40.1 kDa
100 µg/$494
FBXL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
46.9 kDa
100 µg/$494
Viewing 1-8 of 8 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).