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FBXL15
F-box And Leucine-rich Repeat Protein 15
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.
| Gene Name: | F-box And Leucine-rich Repeat Protein 15 |
| Family/Subfamily: | F-Box |
| Synonyms: | FBXL15, F-box only protein 37, FBXO37, F-box/LRR-repeat protein 15, JET, Fbl15 |
| Target Sequences: | AL121928 CAC08404.1 |
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