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20700 44th Avenue W
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FBP1
fructose-1,6-bisphosphatase 1
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
| Gene Name: | fructose-1,6-bisphosphatase 1 |
| Synonyms: | FBP1, Fructose-bisphosphatase 1, FBP, Fructose 1,6-bisphosphatase, Fructose-1,6-bisphosphatase 1, Growth-inhibiting protein 17, FBPase 1 |
| Target Sequences: | NM_000507 NP_000498.2 P09467 |
Publications (2)
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