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FBP1

fructose-1,6-bisphosphatase 1

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

Gene Name: fructose-1,6-bisphosphatase 1
Synonyms: FBP1, Fructose-bisphosphatase 1, FBP, Fructose 1,6-bisphosphatase, Fructose-1,6-bisphosphatase 1, Growth-inhibiting protein 17, FBPase 1
Target Sequences: NM_000507 NP_000498.2 P09467

Publications (2)

1
Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity. Guoqing Wang, Howard H Lou, Jacqueline Salit, Philip L Leopold, Sharon Driscoll, Juergen Schymeinsky, Karsten Quast, Sudha Visvanathan, Jay S Fine, Matthew J Thomas, Ronald G Crystal. Respiratory research. 2019 August;20:196. [Full Text Article] [PubMed:31443657] [PMC:PMC6708250] Related Antibodies: LS-B8080.
2
Proteomic Signature of Acute Liver Failure: From Discovery and Verification in a Pig Model to Confirmation in Humans. Jie Wang, Zeyu Sun, Jing Jiang, Daxian Wu, Xiaoli Liu, Zhongyang Xie, Ermei Chen, Danhua Zhu, Chao Ye, Xiaoqian Zhang, Wenqian Chen, Hongcui Cao, Lanjuan Li. Molecular & cellular proteomics : MCP. 2017 Jul;;16:1188-1199. [Full Text Article] [PubMed:28336726] [PMC:PMC5500754]

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Products
Antibodies (24)
Primary (24)
FBP1 (24)
Human (24)
Mouse (17)
Rat (6)
Dog (3)
Monkey (3)
Zebrafish (3)
IHC (11)
IHC-P (9)
WB (22)
ELISA (5)
ICC (1)
IF (4)
IP (1)
Peptide-ELISA (1)
rabbit (23)
mouse (1)
Product Group
IHCPlus (3)
IgG (20)
polyclonal pc (24)
APC Conjugated (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (16)
aa114-163 (4)
aa1-31 (1)
aa125-156 (1)
No (23)
Yes (1)
FBP1 Antibody - Anti-FBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FBP1 Rabbit anti-Human Polyclonal (aa114-163) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
FBP1 Antibody - Anti-FBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FBP1 Rabbit anti-Human Polyclonal (aa114-163) (HRP) Antibody
Zebrafish, Rat, Mouse, Dog, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
FBP1 Antibody - Anti-FBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FBP1 Rabbit anti-Human Polyclonal (aa114-163) (Biotin) Antibody
Zebrafish, Rat, Mouse, Dog, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
FBP1 Antibody - Anti-FBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FBP1 Rabbit anti-Human Polyclonal (aa114-163) (FITC) Antibody
Zebrafish, Rat, Mouse, Dog, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$442
FBP1 Antibody - Anti-FBP1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
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FBP1 Rabbit anti-Human Polyclonal (aa125-156) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
FBP1 Antibody - Immunohistochemical analysis of FBP1 staining in mouse pancreas formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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FBP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
FBP1 Antibody - Immunofluorescence analysis of MCF-7 cells.
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FBP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
FBP1 Antibody - Anti-FBP1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
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FBP1 Rabbit anti-Human Polyclonal (aa1-31) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
FBP1 Antibody - Immunohistochemistry of paraffin-embedded Human prostate cancer using FBP1 Polyclonal Antibody at dilution of 1:40.
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FBP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
FBP1 Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using FBP1 Polyclonal Antibody at dilution of 1:30.
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FBP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
FBP1 Antibody - Immunohistochemistry of paraffin-embedded human kidney tissue at dilution 1:100
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FBP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
FBP1 Antibody - 1:100 staining mouse heart tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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FBP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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FBP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
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FBP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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FBP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$331
FBP1 Antibody - Western blot All Lanes:FBP1 antibody at 3.06ug/ml Lane 1:mouse liver tissue Lane 2:mouse kidney tissue Secondary Goat polyclonal to rabbit at 1/10000 dilution Predicted band size: 37kDa Observed band size: 37kDa
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FBP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µl/$294; 100 µl/$360
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FBP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
100 µg/$749
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FBP1 Rabbit anti-Human Polyclonal (HRP) Antibody
Mouse, Human
WB
HRP Conjugated
100 µl/$937
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FBP1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$937
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FBP1 Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Human
WB
FITC Conjugated
100 µl/$937
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FBP1 Rabbit anti-Human Polyclonal (APC) Antibody
Mouse, Human
WB
APC Conjugated
100 µl/$937
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FBP1 Rabbit anti-Human Polyclonal (PE) Antibody
Mouse, Human
WB
PE Conjugated
100 µl/$937
FBP1 Antibody - Immunochemical staining of human FBP1 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
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FBP1 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µl/$412
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FBP1 Mouse anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µg/$705
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).