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FBN1 / Fibrillin 1
fibrillin 1
Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.
| Gene Name: | fibrillin 1 |
| Synonyms: | FBN1, ACMICD, Fibrillin 1, Fibrillin-1, FBN, ECTOL1, GPHYSD2, MASS, MFS1, OCTD, SSKS, WMS2, Fibrillin 1 (Marfan syndrome), Fibrillin 15, SGS, WMS |
| Target Sequences: | NM_000138 P35555 |
Publications (3)
1
Defining the Extracellular Matrix of Rhabdomyosarcoma. Xiaolei Lian, J Steffan Bond, Narendra Bharathy, Sergei P Boudko, Elena Pokidysheva, Jack F Shern, Melvin Lathara, Takako Sasaki, Teagan Settelmeyer, Megan M Cleary, Ayeza Bajwa, Ganapati Srinivasa, Christopher P Hartley, Hans Peter Bächinger, Atiya Mansoor, Sakir H Gultekin, Noah E Berlow, Charles Keller. Frontiers in oncology. 2021 March;11:601957. [Full Text Article]
[PubMed:33708626]
[PMC:PMC7942227]
Related Antibodies: LS-B5512.
2
FBXO2 Promotes Proliferation of Endometrial Cancer by Ubiquitin-Mediated Degradation of FBN1 in the Regulation of the Cell Cycle and the Autophagy Pathway. Xiaoxia Che, Fangfang Jian, Ying Wang, Jingjing Zhang, Jian Shen, Qi Cheng, Xi Wang, Nan Jia, Weiwei Feng. Frontiers in cell and developmental biology. 2020 September;8:843. [Full Text Article]
[PubMed:32984335]
[PMC:PMC7487413]
Related Antibodies: LS-B5512.
3
Impairment of chondrogenesis and microfibrillar network in Adamtsl2 deficiency. Laure Delhon, Clémentine Mahaut, Nicolas Goudin, Emilie Gaudas, Kevin Piquand, Wilfried Le Goff, Valérie Cormier-Daire, Carine Le Goff. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 Feb;33:2707-2718. [Full Text Article]
[PubMed:30303737]
Related Antibodies: LS-C358981.
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Proteins
(20)
Type
Over-Expression Lysate
(2)
Recombinant
(18)
Target
FBN1 / Fibrillin 1
(20)
Publications
No
(20)
Tag
6His, N-terminus
(2)
8His, N-terminus
(3)
GST, N-terminus
(1)
His
(5)
His, N-Terminal
(1)
His,C-terminus
(1)
His,N-terminus
(1)
His-GST
(4)
Myc-DDK (Flag)
(2)
Species
Human
(11)
Mouse
(5)
Rat
(3)
Source
293T Cells
(1)
E. coli
(13)
HEK 293 Cells
(1)
Human Cells
(2)
Mammalian Cells
(2)
Wheat Germ Extract
(1)
Purification
Purified
(2)
Low Endotoxin Level
Low endotoxin level
(5)
293T Cells
Myc-DDK (Flag)
312.24 kDa
20 µg/$215
E. coli
6His, N-terminus
20.8 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
E. coli
His-GST
47.2 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
E. coli
6His, N-terminus
22.7 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
HEK 293 Cells
Myc-DDK (Flag)
312.24 kDa
100 µg/$710
E. coli
His, N-Terminal
15.9kDa
10 µg/$288; 50 µg/$487; 200 µg/$972; 100 µg/$780; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
Mammalian Cells
8His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.9 kDa
10 µg/$317; 50 µg/$524
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
His,C-terminus
Less than 0.1 EU/µg protein (determined by LAL method).
~18 kDa (SDS-PAGE)
10 µg/$344
Mammalian Cells
His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
17 kDa
10 µg/$317; 50 µg/$524
Human Cells
8His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
17kD
10 µg/$321; 1 mg/$2,353; 500 µg/$1,585; 50 µg/$534
Human Cells
8His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.9kD
50 µg/$534; 10 µg/$321; 1 mg/$2,353; 500 µg/$1,585
E. coli
His-GST
48.3 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
E. coli
His-GST
60.6 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
E. coli
His-GST
51.2 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
E. coli
His
21.2 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
E. coli
His
22.3 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
E. coli
His
17.0 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
E. coli
His
22.4 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
E. coli
His
19.0 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
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