FAT10 / UBD

ubiquitin D

Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

FAT10 / UBD (8)

Publications

No (8)

Tag

GST (1)

His (1)

His-SUMO (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (6)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human FAT10 / UBD Protein (Recombinant GST) (Full Length) - LS-G32206

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

44.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human FAT10 / UBD Protein (Recombinant His-SUMO) (Full Length) - LS-G21304

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

34.46 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human FAT10 / UBD Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68965

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18.3 kDa

Price:

20 µg/$1,107

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Human FAT10 / UBD Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83517

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18.3 kDa

Price:

20 µg/$150

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FAT10 / UBD Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100813

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18.3 kDa

Price:

100 µg/$494

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Human FAT10 / UBD Protein (Recombinant His) - LS-G1428

Source:

E. coli

Tag:

His

Price:

10 µg/$304; 50 µg/$429; 20 µg/$373; 100 µg/$605; 250 µg/$1,036; 500 µg/$1,555

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Human FAT10 / UBD Protein (Recombinant His-T7) (aa1-165) - LS-G14217

Source:

E. coli

Tag:

His-T7

Molecular Weight:

22.3 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Rat FAT10 / UBD Protein (Recombinant His-T7) (aa1-155) - LS-G14223

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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