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FASTK / FAST is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.
Gene Name: | Fas-activated serine/threonine kinase |
Family/Subfamily: | Protein Kinase , FAST |
Synonyms: | FASTK, FAST, FAST kinase |
Target Sequences: | NM_006712 NP_006703.1 Q14296 |
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