FAP Alpha

fibroblast activation protein, alpha

Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16651416, PubMed:16410248, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

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Proteins (12)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

FAP Alpha (12)

Application

SDS-PAGE (1)

Publications

No (12)

Tag

6His-SUMO, N-terminus (1)

GST (2)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His, N-terminus + His, C-terminus (1)

His,N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Mouse (3)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (3)

Human Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

Biologically Active

Biologically active (1)

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Human FAP Alpha Protein (Recombinant His, N-Terminal) (aa523-760) - LS-G14945

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

30.4 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Mouse FAP Alpha Protein (Recombinant 6His-SUMO, N-terminus) (aa26-761) - LS-G64301

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

100 µg/$1,128; 20 µg/$721

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Mouse FAP Alpha Protein (Recombinant His-T7) (aa542-761) - LS-G24879

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.4 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human FAP Alpha Protein (Recombinant GST) (aa26-760) - LS-G20724

Source:

E. coli

Tag:

GST

Molecular Weight:

112.4 kD

Price:

100 µg/$420; 1 mg/$1,355; 20 µg/$323

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Human FAP Alpha Protein (Recombinant His) (Leu26-Asp760) - LS-G97454

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

87.2 kDa

Price:

50 µg/$1,189; 1 mg/$6,061

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Human FAP Alpha Protein (Recombinant His,N-terminus) (Leu26-Asp760) - LS-G48474

Source:

HEK 293 Cells

Tag:

His,N-terminus

Application:

SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human FAP consists of 751 amino acids and predicts a molecular mass of 87.2 kDa. As a result of glycosylation, rh FAP migrates as approximately 90 kDa band in SDS-PAGE under reducing conditions.

Price:

50 µg/$519; 1 mg/$3,615

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Human FAP Alpha Protein (Recombinant GST, N-terminus) (aa525-624) - LS-G58532

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human FAP Alpha Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68094

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.5 kDa

Price:

20 µg/$1,107

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Human FAP Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81432

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.5 kDa

Price:

20 µg/$150

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Human FAP Alpha Protein (Recombinant GST) (Full Length) - LS-G28438

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

114.1 kDa

Price:

2 µg/$439

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FAP Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100302

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.5 kDa

Price:

100 µg/$494

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Mouse FAP Alpha Protein (Recombinant His, N-terminus + His, C-terminus) - LS-G146294

Source:

E. coli

Tag:

His, N-terminus + His, C-terminus

Molecular Weight:

38kDa

Price:

20 µg/$270; 100 µg/$390

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