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FAP-1 / PTPN13

protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)

FAP-1 / PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Gene Name: protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
Family/Subfamily: Protein Phosphatase , NT7
Synonyms: PTPN13, FAP-1, HPTP1E, HPTPE1, Fas associated phosphatase 1, Phosphatase rip, PTP-BAS, PTP-E1, PTP-BL, PTP1E, PTPLE, PNP1, PTPL1
Target Sequences: NM_006264 NP_006255.1 Q12923

Publications (1)

1
The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation. Wang Y, Hall RA, Lee M, Kamgar-Parsi A, Bi X, Baudry M. Scientific reports. 2017 7:11771. (WB; Human) [Full Text Article] [PubMed:28924170] [PMC:PMC5603515] Related Antibodies: LS-C148268.

☰ Filters
Antibodies (39)
Proteins (6)
Over-Expression Lysate (2)
Primary (39)
Recombinant (4)
FAP-1 / PTPN13 (45)
Human (23)
Mouse (12)
Rat (11)
Monkey (1)
IHC (8)
IHC-Fr (2)
IHC-P (4)
WB (33)
ELISA (5)
ICC (1)
IF (2)
IP (4)
rabbit (39)
IgG (8)
polyclonal pc (39)
APC (3)
APC Conjugated (3)
Biotin Conjugated (4)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (3)
Unconjugated (15)
aa1279-1883 (2)
aa1760-1775 (1)
No (44)
Yes (1)
GST, N-terminus (1)
His-T7, N-terminus (3)
Myc-DDK (Flag) (2)
Human (3)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (1)
FAP-1 / PTPN13 Antibody - Immunocytochemistry of FAP-1 in cell lines using Polyclonal Antibody to FAP-1 at 1:2000. In ovarian carcinoma cell lines FAP-1 expression was detected in SK-OV-3 and OVCAR-3, but not in BG-1 or HEY. Human 293 kidney and Jurkat T cell lines were used as positive and negative controls, respectively. The staining data correlates with the western blot data (figure to the left).
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal (aa1279-1883) Antibody
Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
FAP-1 / PTPN13 Antibody - Western blot of LOVO cell lysate using FAP-1 Antibody
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal (aa1760-1775) Antibody
Human, Monkey
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal (aa1279-1883) Antibody
Human
ICC, IF, IHC, IP, WB
Unconjugated
50 µl/$393
FAP-1 / PTPN13 Antibody - Immunohistochemistry image at a dilution of 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
FAP-1 / PTPN13 Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using FAP-1 antibody.
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
50 µl/$393
FAP-1 / PTPN13 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using PTPN13 Polyclonal Antibody at dilution of 1:30.
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
FAP-1 / PTPN13 Antibody - Western blot analysis of mouse-lung lysate, antibody was diluted at 1000. Secondary antibody was diluted at 1:20000.
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FAP-1 / PTPN13 Antibody
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FAP-1 / PTPN13 Rabbit anti-Mouse Polyclonal Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
FAP-1 / PTPN13 Antibody
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FAP-1 / PTPN13 Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
FAP-1 / PTPN13 Antibody
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FAP-1 / PTPN13 Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
FAP-1 / PTPN13 Antibody
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FAP-1 / PTPN13 Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
FAP-1 / PTPN13 Antibody
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FAP-1 / PTPN13 Rabbit anti-Mouse Polyclonal (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
FAP-1 / PTPN13 Antibody
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FAP-1 / PTPN13 Rabbit anti-Mouse Polyclonal (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
FAP-1 / PTPN13 Antibody
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FAP-1 / PTPN13 Rabbit anti-Mouse Polyclonal (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
FAP-1 / PTPN13 Antibody
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FAP-1 / PTPN13 Rabbit anti-Mouse Polyclonal (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
FAP-1 / PTPN13 Antibody - Western Blot; Sample: Recombinant PTPN13, Human.
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
FAP-1 / PTPN13 Antibody - Western Blot; Sample: Recombinant PTPN13, Human.
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
FAP-1 / PTPN13 Antibody - Western Blot; Sample: Recombinant PTPN13, Human.
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
FAP-1 / PTPN13 Antibody - Western Blot; Sample: Recombinant PTPN13, Human.
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
FAP-1 / PTPN13 Antibody - Western Blot; Sample: Recombinant PTPN13, Human.
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
FAP-1 / PTPN13 Antibody - Western blot analysis of extracts of various cell lines, using PTPN13 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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FAP-1 / PTPN13 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Select
FAP-1 / PTPN13 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µg/$357
Viewing 1-25 of 45 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).