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FANCC

Fanconi anemia, complementation group C

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C.

Gene Name: Fanconi anemia, complementation group C
Synonyms: FANCC, FAC, Fanconi anemia group C protein, FA3, Protein FACC, FACC
Target Sequences: NM_000136 NP_000127.2 Q00597

Publications (5)

1
A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD. Blood. 1999 94:3737-47. [PubMed:10572087]
2
Posttranscriptional cell cycle-dependent regulation of human FANCC expression. Heinrich MC, Silvey KV, Stone S, Zigler AJ, Griffith DJ, Montalto M, Chai L, Zhi Y, Hoatlin ME. Blood. 2000 95:3970-7. [PubMed:10845936]
3
Aberrant Fanconi anaemia protein profiles in acute myeloid leukaemia cells. Xie Y, de Winter JP, Waisfisz Q, Nieuwint AW, Scheper RJ, Arwert F, Hoatlin ME, Ossenkoppele GJ, Schuurhuis GJ, Joenje H. British journal of haematology. 2000 111:1057-64. [PubMed:11167740]
4
HES1 is a novel interactor of the Fanconi anemia core complex. Tremblay CS, Huang FF, Habi O, Huard CC, Godin C, Lvesque G, Carreau M. Blood. 2008 112:2062-70. (ICC, WB; Human) [PubMed:18550849]
5
Human pluripotent stem cell models of Fanconi Anaemia deficiency reveal an important role for Fanconi Anaemia proteins in cellular reprogramming and survival of haematopoietic progenitors. Park SJ, Ciccone SL, Beck BD, Hwang B, Freie B, Clapp DW, Lee SH. Stem cells (Dayton, Ohio). 2012 (WB) [PubMed:23280624]
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Products
Antibodies (43)
Primary (43)
FANCC (43)
Human (43)
Mouse (3)
Rat (2)
Chimpanzee (4)
IHC (13)
IHC-P (4)
WB (39)
Flo (7)
ELISA (19)
ICC (6)
IF (12)
IP (1)
Peptide-ELISA (1)
rabbit (31)
mouse (12)
Product Group
IHCPlus (3)
IgG (22)
IgG1 (2)
IgG2a (2)
IgG2b,k (7)
monoclonal mc (11)
polyclonal pc (32)
6E7 (1)
OTI11B2 (2)
OTI8A7 (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (5)
Carrier-free (2)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Preservative Free (1)
Unconjugated (22)
aa527-555 (7)
aa1-284 (4)
aa98-147 (4)
C-Terminus (3)
aa1-101 (1)
aa1-558 (1)
aa450-558 (1)
No (43)
FANCC Antibody - Anti-FANCC antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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FANCC Rabbit anti-Human Polyclonal Antibody
Human, Chimpanzee
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
FANCC Antibody - Immunofluorescence analysis of U2OS cells using FANCC antibody. Blue: DAPI for nuclear staining.
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FANCC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
FANCC Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
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FANCC Mouse anti-Human Monoclonal (6E7) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
FANCC Antibody - Immunofluorescent analysis of FANCC staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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FANCC Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
FANCC Antibody - FANCC Antibody IHC of formalin-fixed and paraffin-embedded testis tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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FANCC Rabbit anti-Human Polyclonal (aa527-555) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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FANCC Rabbit anti-Human Polyclonal (aa527-555) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200 µl/$734
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FANCC Rabbit anti-Human Polyclonal (aa527-555) (Biotin) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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FANCC Rabbit anti-Human Polyclonal (aa527-555) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
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FANCC Rabbit anti-Human Polyclonal (aa527-555) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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FANCC Rabbit anti-Human Polyclonal (aa527-555) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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FANCC Rabbit anti-Human Polyclonal (aa527-555) (PE) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
FANCC Antibody - Anti-FANCC antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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FANCC Rabbit anti-Human Polyclonal (C-Terminus) (Preservative Free) Antibody
Human
IHC, IHC-P, WB
Unconjugated, Preservative Free
50 µg/$460
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FANCC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
FANCC Antibody - FANCC Antibody - Western Blot on cells overexpressing FANCC probed with 1. pre-immune serum and 2. anti-FANCC .
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FANCC Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IF, IP, WB
Unconjugated
0.1 ml/$386
FANCC Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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FANCC Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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FANCC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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FANCC Mouse anti-Human Monoclonal (aa1-101) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
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FANCC Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
Select
FANCC Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
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FANCC Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
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FANCC Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
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FANCC Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
FANCC Antibody - Immunohistochemistry of paraffin-embedded human kidney tissue using FANCC Antibody at dilution of 1:100
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FANCC Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
FANCC Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY FANCC. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FANCC. (1:2000)
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FANCC Mouse anti-Human Monoclonal (aa1-284) (Carrier-free) (OTI8A7) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
FANCC Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY FANCC. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FANCC. (1:2000)
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FANCC Mouse anti-Human Monoclonal (aa1-284) (Carrier-free) (OTI11B2) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).