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FAM175A / CCDC98
family with sequence similarity 175, member A
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
| Gene Name: | family with sequence similarity 175, member A |
| Synonyms: | FAM175A, Abraxas protein, ABRAXAS, CCDC98, ABRA1, Protein FAM175A |
| Target Sequences: | AK023676 BAB14635.1 Q6UWZ7 |
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