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FAM125B
multivesicular body subunit 12B
FAM125B is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | multivesicular body subunit 12B |
| Synonyms: | MVB12B, FAM125B, C9orf28 |
| Target Sequences: | NM_033446 NP_258257.1 Q9H7P6 |
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