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FAM123B / WTX
APC membrane recruitment protein 1
Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.
| Gene Name: | APC membrane recruitment protein 1 |
| Synonyms: | AMER1, FAM123B, OSCS, RP11-403E24.2, WTX |
| Target Sequences: | NP_689637.3 Q5JTC6 |
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