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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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FAK / Focal Adhesion Kinase

protein tyrosine kinase 2

Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.

Gene Name: protein tyrosine kinase 2
Family/Subfamily: Protein Kinase , Focal Adhesion Kinase
Synonyms: PTK2, FADK, Fadk1, Focal adhesion kinase, FRNK, FADK 1, Focal adhesion kinase 1, FAK1, p125FAK, PPP1R71, Protein-tyrosine kinase 2, PTK2 protein tyrosine kinase 2, FAK, pp125 FA kinase, Pp125FAK
Target Sequences: NM_005607 NP_005598.3 Q05397

Publications (3)

1
Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro. Lau GM, Lau GM, Yu GL, Gelman IH, Gutowski A, Hangauer D, Fang JW. Digestive diseases and sciences. 2009 54:1465-74. (IHC) [PubMed:18979199]
2
Neutrophil granulocytes promote the migratory activity of MDA-MB-468 human breast carcinoma cells via ICAM-1. Strell C, Lang K, Niggemann B, Zaenker KS, Entschladen F. Experimental cell research. 2010 316:138-48. (WB) [PubMed:19747913]
3
Leptin stimulates the migration of colon carcinoma cells by multiple signaling pathways. Ratke J, Entschladen F, Niggemann B, Znker KS, Lang K. Endocrine-related cancer. 2010 17:179-89. (WB) [PubMed:19952122]

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IHC (106)
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Viewing 1-25 of 243 items
FAK / Focal Adhesion Kinase Antibody - Anti-FAK / Focal Adhesion Kinase antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Mouse, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK / Focal Adhesion Kinase antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Mouse, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK / Focal Adhesion Kinase antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Mouse, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK / Focal Adhesion Kinase antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Mouse, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK / Focal Adhesion Kinase antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Mouse, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK / Focal Adhesion Kinase antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Mouse, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK / Focal Adhesion Kinase antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Mouse, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody
Select
Neuroscience
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Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Rat, Hamster, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
FAK / Focal Adhesion Kinase Antibody
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Rat, Hamster, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Rat, Hamster, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody
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Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Rat, Hamster, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody
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Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Rat, Hamster, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Rat, Hamster, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Rat, Hamster, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK antibody IHC of human colon, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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Rabbit Polyclonal (IgG1) to Human FAK / Focal Adhesion Kinase
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50µl   $425.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Mouse, Dog, Rat, Hamster, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Mouse, Dog, Rat, Hamster, Bat, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Mouse, Dog, Rat, Hamster, Bat, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Mouse, Dog, Rat, Hamster, Bat, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Mouse, Dog, Rat, Hamster, Bat, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Mouse, Dog, Rat, Hamster, Bat, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Chicken, Bovine, Mouse, Dog, Rat, Hamster, Bat, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
FAK / Focal Adhesion Kinase Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human FAK / Focal Adhesion Kinase
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µl   1mg/ml   $505.00
FAK / Focal Adhesion Kinase Antibody - Anti-FAK antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal to Human FAK / Focal Adhesion Kinase
Frog, Chicken, Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
10blot   $605.00
FAK / Focal Adhesion Kinase Antibody - Immunohistochemistry of paraffin-embedded mouse spleen using PTK2 antibodyat dilution of 1:100 (40x lens).
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Rabbit Monoclonal to Human FAK / Focal Adhesion Kinase
Mouse, Rat, Human
Flo, IF, IHC, IP, WB
Unconjugated
50µl   $295.00; 100µl   $385.00; 200µl   $560.00

Viewing 1-25 of 243 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).