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FAK / Focal Adhesion Kinase

protein tyrosine kinase 2

Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.

Gene Name: protein tyrosine kinase 2
Family/Subfamily: Protein Kinase , Focal Adhesion Kinase
Synonyms: PTK2, FADK, Fadk1, Focal adhesion kinase, FRNK, FADK 1, Focal adhesion kinase 1, FAK1, p125FAK, PPP1R71, Protein-tyrosine kinase 2, PTK2 protein tyrosine kinase 2, FAK, pp125 FA kinase, Pp125FAK
Target Sequences: NM_005607 NP_005598.3 Q05397

Publications (3)

1
Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro. Lau GM, Lau GM, Yu GL, Gelman IH, Gutowski A, Hangauer D, Fang JW. Digestive diseases and sciences. 2009 54:1465-74. (IHC) [PubMed:18979199]
2
Neutrophil granulocytes promote the migratory activity of MDA-MB-468 human breast carcinoma cells via ICAM-1. Strell C, Lang K, Niggemann B, Zaenker KS, Entschladen F. Experimental cell research. 2010 316:138-48. (WB) [PubMed:19747913]
3
Leptin stimulates the migration of colon carcinoma cells by multiple signaling pathways. Ratke J, Entschladen F, Niggemann B, Znker KS, Lang K. Endocrine-related cancer. 2010 17:179-89. (WB) [PubMed:19952122]

☰ Filters
Antibodies (237)
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FAK / Focal Adhesion Kinase (273)
Human (230)
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1297CT261.163.145 (1)
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FAK / Focal Adhesion Kinase Antibody - Anti-FAK / Focal Adhesion Kinase antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
FAK / Focal Adhesion Kinase Antibody
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Neuroscience
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FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Bovine, Rat, Hamster, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
FAK / Focal Adhesion Kinase Antibody - Immunofluorescence analysis of SH-SY-5Y cells using PTK2 antibody.
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FAK / Focal Adhesion Kinase Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$306; 100 µl/$381; 200 µl/$489
FAK / Focal Adhesion Kinase Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with PTK2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (aa821-848) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$381
FAK / Focal Adhesion Kinase Antibody - Anti-FAK antibody IHC of human colon, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (aa706-1052) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$485
FAK / Focal Adhesion Kinase ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$721
FAK / Focal Adhesion Kinase Antibody - IHC of p-FAK (Y925) pAb in paraffin-embedded human brain tissue.
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FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (pTyr925) Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$327; 100 µl/$409
FAK / Focal Adhesion Kinase ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$571
FAK / Focal Adhesion Kinase ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$721
FAK / Focal Adhesion Kinase Antibody - Anti-FAK antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (Kinase Domain) Antibody
Chicken, Bovine, Mouse, Dog, Rat, Hamster, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
FAK / Focal Adhesion Kinase Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PTK2 mouse monoclonal antibody.
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FAK / Focal Adhesion Kinase Mouse anti-Human Monoclonal (OTI4G7) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$409
FAK / Focal Adhesion Kinase Antibody - Immunohistochemical analysis of Focal Adhesion Kinase staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$289
FAK / Focal Adhesion Kinase Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using FAK (Phospho-Ser910) Antibody. The picture on the right is blocked with the phospho peptide.
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FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (pSer910) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$306; 100 µl/$366
FAK / Focal Adhesion Kinase Antibody - Immunofluorescent analysis of Focal Adhesion Kinase (pY925) staining in NIH3T3 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (pTyr925) Antibody
Chicken, Zebrafish, Mouse, Rat, Human
ICC, IF, WB
Unconjugated
100 µl/$305
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FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (860-940 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
FAK / Focal Adhesion Kinase Antibody - Western blot of Phospho-FAK (Y397) antibody
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FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (340-420 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
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FAK / Focal Adhesion Kinase Mouse anti-Chicken Monoclonal Antibody
Chicken, Rodent, Human
IF, IP
Unconjugated
100 µg/$533; 200 µg/$825
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FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (pTyr577) Antibody
Mouse, Human
ELISA, WB
Unconjugated
10 Blots/$682
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FAK / Focal Adhesion Kinase Mouse anti-Human Monoclonal (aa103-553) Antibody
Chicken, Mouse, Rat, Human
IP, WB
Unconjugated
100 µg/$688
FAK / Focal Adhesion Kinase Antibody - 1:200 staining human pancreas tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (pTyr576) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
FAK / Focal Adhesion Kinase Antibody - 1:200 staining mouse heart tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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FAK / Focal Adhesion Kinase Rabbit anti-Human Polyclonal (pTyr397) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
FAK / Focal Adhesion Kinase Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-PTK2 mouse monoclonal antibody.
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FAK / Focal Adhesion Kinase Mouse anti-Human Monoclonal (OTI4D11) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$409
FAK / Focal Adhesion Kinase Antibody - IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-PTK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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FAK / Focal Adhesion Kinase Mouse anti-Human Monoclonal (OTI4A8) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$409
FAK / Focal Adhesion Kinase Antibody - FAK Antibody in Immunohistochemistry (IHC)
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FAK / Focal Adhesion Kinase Mouse anti-Human Monoclonal (10H7) Antibody
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
100 µl/$494
FAK / Focal Adhesion Kinase Antibody - FAK Antibody in Immunofluorescence (IF)
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FAK / Focal Adhesion Kinase Mouse anti-Human Monoclonal (10H7E9) Antibody
Human
Flo, ICC, IF, WB
Unconjugated
100 µl/$494
Viewing 1-25 of 273 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).