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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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FAC1 / BPTF

bromodomain PHD finger transcription factor

FAC1 / BPTF was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely.

Gene Name: bromodomain PHD finger transcription factor
Synonyms: BPTF, FAC1, FALZ, Fetal Alz-50 clone 1 protein, Fetal Alz-50 reactive clone 1, Fetal Alzheimer antigen, NURF301
Target Sequences: NM_004459 NP_004450.3 Q12830

Filtered By: None
Target
FAC1 / BPTF (7)
Reactivity
Human (7)
Application
IHC (3)
IHC-P (3)
WB (5)
DB (2)
ELISA (1)
IF (2)
IP (2)
Host
rabbit (3)
mouse (4)
Isotype
IgG (2)
IgG1 (3)
IgG2b (1)
Clonality
monoclonal mc (4)
polyclonal pc (3)
Clone
2343C3a (2)
2F10 (1)
Format
Unconjugated (7)
Epitope
aa1350-1400 (3)
Publications
No (7)
Showing 1-7 of 7 results

FAC1 / BPTF Antibody (clone 2F10) IHC-plus™ LS-B10731
Mouse Monoclonal [clone 2F10] (IgG2b) to Human FAC1 / BPTF
Human
ELISA IHC IHC-P WB
Unconjugated
50µl  $425.00
Anti-FAC1 / BPTF antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Western blot using BPTF monoclonal antibody against HEK293 (1) and BPTF (AA: 503-670)-hIgGFc transfected HEK293 (2) cell lysate.
Anti-FAC1 / BPTF antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Western blot using BPTF monoclonal antibody against HEK293 (1) and BPTF (AA: 503-670)-hIgGFc transfected HEK293 (2) cell lysate.

FAC1 / BPTF Antibody (aa1350-1400) LS-C77297
Rabbit Polyclonal to Human FAC1 / BPTF
Human
IP WB
Unconjugated
100µl 0.2mg/ml  $770.00

FAC1 / BPTF Antibody LS-C77296
Mouse Monoclonal (IgG1) to Human FAC1 / BPTF
Human
WB
Unconjugated
50µg 0.1mg/ml  $385.00

FAC1 / BPTF Antibody (aa1350-1400) LS-C287806
Rabbit Polyclonal (IgG) to Human FAC1 / BPTF
Human
IF IHC IHC-P IP WB
Unconjugated
100µl 0.2mg/ml  $395.00
Detection of Human FALZ/BPTF by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-FALZ/BPTF used at a dilution of 1:200 (1 Detection: DAB.
Detection of Human FALZ/BPTF by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-FALZ/BPTF antibody used for WB at 0.04 ug/ml (A) and 0.1 ug/ml (B) and used for IP at 3 ug/mg lysate (B). Detection: Chemiluminescence with exposure times of 10 seconds (A) and 1 second (B).
Detection of Human FALZ/BPTF by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-FALZ/BPTF used at a dilution of 1:200 (1 Detection: DAB.
Detection of Human FALZ/BPTF by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-FALZ/BPTF antibody used for WB at 0.04 ug/ml (A) and 0.1 ug/ml (B) and used for IP at 3 ug/mg lysate (B). Detection: Chemiluminescence with exposure times of 10 seconds (A) and 1 second (B).

FAC1 / BPTF Antibody (aa1350-1400) LS-C286732
Rabbit Polyclonal (IgG) to Human FAC1 / BPTF
Human
IF IHC IHC-P
Unconjugated
100µl  $545.00
FFPE section of human breast carcinoma.  Rabbit anti-FALZ/BPTF IHC Antibody, Affinity Purified used at a dilution of 1:250.
FFPE section of human colon carcinoma. Rabbit anti-FALZ/BPTF IHC Antibody, Affinity Purified used at a dilution of 1:250.
FFPE section of human breast carcinoma.  Rabbit anti-FALZ/BPTF IHC Antibody, Affinity Purified used at a dilution of 1:250.
FFPE section of human colon carcinoma. Rabbit anti-FALZ/BPTF IHC Antibody, Affinity Purified used at a dilution of 1:250.

FAC1 / BPTF Antibody (clone 2343C3a) LS-C342530
Mouse Monoclonal [clone 2343C3a] (IgG1) to Human FAC1 / BPTF
Human
DB WB
Unconjugated
100µg 0.1mg/ml  $375.00
Western blot analysis of immunized recombinant protein, using anti-FALZ monoclonal antibody.
Western blot analysis of immunized recombinant protein, using anti-FALZ monoclonal antibody.

FAC1 / BPTF Antibody (clone 2343C3a) LS-C184489
Mouse Monoclonal [clone 2343C3a] (IgG1) to Human FAC1 / BPTF
Human
DB
Unconjugated
50µg 0.1mg/ml  $325.00
Showing 1-7 of 7 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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