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F9 / Factor IX

coagulation factor IX

F9 / Factor IX is a vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.

Gene Name: coagulation factor IX
Family/Subfamily: Protease , Serine S1
Synonyms: F9, Christmas Disease, Coagulation factor IX, Factor IX Deficiency, FIX, HEMB, F9 p22, Factor 9, Factor IX, Factor IX F9, FIX F9, Haemophilia B, THPH8, Christmas factor, Hemophilia B, PTC, Serine protease
Target Sequences: NM_000133 NP_000124.1 P00740

Publications (4)

1
Targeted introduction and effective expression of hFIX at the AAVS1 locus in mesenchymal stem cells. Li SJ, Luo Y, Zhang LM, Yang W, Zhang GG. Molecular medicine reports. 2017 March;15:1313-1318. [Full Text Article] [PubMed:28112377] [PMC:PMC5367337]
2
Preclinical development of plant-based oral immune modulatory therapy for haemophilia B. Aparajitha Srinivasan, Roland W Herzog, Imran Khan, Alexandra Sherman, Thais Bertolini, Tung Wynn, Henry Daniell. Plant biotechnology journal. 2021 Oct;;19:1952-1966. [Full Text Article] [PubMed:33949086] [PMC:PMC8486253]
3
A novel next-generation FVIIIa mimetic, Mim8, has a favorable safety profile and displays potent pharmacodynamic effects: Results from safety studies in cynomolgus monkeys. Brian Lauritzen, Mads Bjelke, Olle Björkdahl, Esther Bloem, Kevin Keane, Marianne Kjalke, Marie Rossen, Solvej Lund Lippert, Karin Nana Weldingh, Mikala Skydsgaard, Stine Kjellev. Journal of thrombosis and haemostasis : JTH. 2022 June;20:1312-1324. [Full Text Article] [PubMed:35191180] [PMC:PMC9314625] Related Antibodies: LS-B7226.
4
A lipoprotein receptor cluster IV mutant preferentially binds amyloid- beta and regulates its clearance from the mouse brain. Sagare AP, Bell RD, Srivastava A, Sengillo JD, Singh I, Nishida Y, Chow N, Zlokovic BV. The Journal of biological chemistry. 2013 May;288:15154-66. [Full Text Article] [PubMed:23580652] [PMC:PMC3663536] Related Antibodies: LS-C23381.
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F9 / Factor IX (27)
Human (7)
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F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
F9 / Factor IX ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Monkey
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$863
F9 / Factor IX ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.1 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma
1 Plate/$594
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma
1 Plate/$764
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma
1 Plate/$782
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Microplate
Human
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
F9 / Factor IX ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
F9 / Factor IX ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
F9 / Factor IX ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
F9 / Factor IX ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
F9 / Factor IX ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
F9 / Factor IX ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
F9 / Factor IX ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
F9 / Factor IX ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
F9 / Factor IX ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
F9 / Factor IX ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$783
F9 / Factor IX ELISA Kit
Select
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$929
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
F9 / Factor IX ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
F9 / Factor IX ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).