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F3 / CD142 / Tissue factor

coagulation factor III (thromboplastin, tissue factor)

F3 / CD142 / Tissue factor is coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.

Gene Name: coagulation factor III (thromboplastin, tissue factor)
Synonyms: F3, CD142, CD142 antigen, TFA, Tissue factor, Thromboplastin, Coagulation factor III
Target Sequences: NM_001993 NP_001984.1 P13726

Publications (4)

1
Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps. Boone BA, Murthy P, Miller-Ocuin J, Doerfler WR, Ellis JT, Liang X, Ross MA, Wallace CT, Sperry JL, Lotze MT, Neal MD, Zeh HJ 3rd. BMC cancer. 2018 June;18:678. [Full Text Article] [PubMed:29929491] [PMC:PMC6013899]
2
Procoagulant extracellular vesicles in amniotic fluid. Lena Hell, Lukas Wisgrill, Cihan Ay, Andreas Spittler, Michael Schwameis, Bernd Jilma, Ingrid Pabinger, Peter Altevogt, Johannes Thaler. Translational research : the journal of laboratory and clinical medicine. 2017 June;184:12-20.e1. [Full Text Article] [PubMed:28236427] [PMC:PMC6544525]
3
Using annexin V-coated magnetic beads to capture active tissue factor-bearing microparticles from body fluids. Frank Gieseler, Hans Gamperl, Frederike Theophil, Inga Stenzel, Tabea Quecke, Hendrik Ungefroren, Hendrik Lehnert. Cell biology international. 2014 Feburary;38:277-81. [Full Text Article] [PubMed:24431236]
4
Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non- and anti-adipogenic in age-dependent manner. Magda Zachara , Pernille Y Rainer , Horia Hashimi , Julie M Russeil, Daniel Alpern, Radiana Ferrero, Maria Litovchenko, Bart Deplancke. The EMBO journal. 2022 September;41:e108206. [Full Text Article] [PubMed:35996853] [PMC:PMC9475530]
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Products
Proteins (18)
Recombinant (18)
F3 / CD142 / Tissue factor (18)
No (17)
Yes (1)
6His, C-terminus (3)
6His, N-terminus (1)
6His-SUMO, N-terminus (1)
Fc (1)
GST, N-terminus (1)
His (5)
His, N-Terminal (2)
His,C-terminus (1)
His-S (1)
His-T7 (1)
Myc-DDK (Flag) (1)
Bovine (1)
Human (9)
Mouse (4)
Rabbit (1)
Rat (3)
E. coli (9)
HEK 293 Cells (1)
Human Cells (4)
Mammalian Cells (3)
Wheat Germ Extract (1)
Purified (4)
Low endotoxin level (7)
F3 / CD142 / Tissue factor Protein - Recombinant Tissue Factor By SDS-PAGE
Select
E. coli
His, N-Terminal
26.6 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
F3 / CD142 / Tissue factor Protein
Select
E. coli
His
20 µg/$361; 100 µg/$739; 4 µg/$261
Select
Mammalian Cells
6His, C-terminus
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.76kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
F3 / CD142 / Tissue factor Protein - Purified recombinant protein F3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
29.5 kDa
20 µg/$1,107
F3 / CD142 / Tissue factor Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
F3 / CD142 / Tissue factor Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
51.8 kDa
20 µg/$721
F3 / CD142 / Tissue factor Protein - Recombinant Tissue Factor By SDS-PAGE
Select
E. coli
His-T7
32.9 kDa
50 µg/$452; 10 µg/$283; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
F3 / CD142 / Tissue factor Protein - Recombinant Tissue Factor By SDS-PAGE
Select
E. coli
His
26.0 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
F3 / CD142 / Tissue factor Protein - Recombinant Tissue Factor By SDS-PAGE
Select
E. coli
His
26.9 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
F3 / CD142 / Tissue factor Protein - Recombinant Tissue Factor By SDS-PAGE
Select
E. coli
His-S
35.0 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
F3 / CD142 / Tissue factor Protein
Select
E. coli
6His, N-terminus
25 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
26.2 kDa
10 µg/$317; 50 µg/$524
F3 / CD142 / Tissue factor Protein - Active Tissue Factor (TF) by WB
Select
E. coli
His, N-Terminal
29kDa
10 µg/$370; 50 µg/$922; 200 µg/$1,577; 100 µg/$1,345; 1 mg/$2,945; 500 µg/$2,397; 5 mg/$6,441; 2 mg/$3,436
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.8 kDa
10 µg/$317; 50 µg/$524
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
27.2 kDa
20 µg/$603
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
26.8 kDa
50 µg/$1,214
Viewing 1-18 of 18 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).