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F2 / Prothrombin / Thrombin
coagulation factor II (thrombin)
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
| Gene Name: | coagulation factor II (thrombin) |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | F2, Prothrombin B-chain, Coagulation factor II, FACTOR II, Prothrombin, PT, RPRGL2, Serine protease, THPH1, Thrombin |
| Target Sequences: | NM_000506 NP_000497.1 P00734 |
Publications (3)
1
Targeting the thrombin receptor modulates inflammation and astrogliosis to improve recovery after spinal cord injury. Radulovic M, Yoon H, Wu J, Mustafa K, Scarisbrick IA. Neurobiology of disease. 2016 93:226-42. (WB; Human)
[Full Text Article]
[PubMed:27145117]
Related Antibodies: LS-C118750.
2
Production and control of coagulation proteins for factor X activation in human endothelial cells and fibroblasts. Clay T Cohen, Nancy A Turner, Joel L Moake. Scientific reports. 2020 Feb;10:2005. [Full Text Article]
[PubMed:32029851]
[PMC:PMC7005260]
3
Maternal plasma proteomics in a rat model of pregnancy complications reveals immune and pro-coagulant gene pathway activation. Tino W Sanchez, Bo Li, Christine Molinaro, Carlos A Casiano, Denise L Bellinger, Eugenia Mata-Greenwood. American journal of reproductive immunology (New York, N.Y. : 1989). 2020 February;83:e13205. [Full Text Article]
[PubMed:31677200]
[PMC:PMC8553409]
☰ Filters
Products
Proteins
(18)
Type
Over-Expression Lysate
(2)
Recombinant
(16)
Target
F2 / Prothrombin / Thrombin
(18)
Publications
No
(18)
Tag
6His, N-terminus
(2)
6His-SUMO, N-terminus
(1)
GST
(1)
GST, N-terminus
(1)
His
(7)
His, N-Terminal
(1)
His-T7
(1)
Myc-DDK (Flag)
(3)
Species
Human
(9)
Mouse
(4)
Rat
(4)
Source
293T Cells
(1)
E. coli
(11)
HEK 293 Cells
(2)
Human Cells
(1)
Wheat Germ Extract
(2)
Yeast
(1)
Purification
Purified
(6)
Low Endotoxin Level
Low endotoxin level
(1)
E. coli
6His, N-terminus
67.6 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
E. coli
His-T7
20.9 kDa
50 µg/$442; 10 µg/$281; 200 µg/$882; 100 µg/$705; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Yeast
6His, N-terminus
67 kDa
100 µg/$570; 20 µg/$395; 1 mg/$1,973
E. coli
His
19.1 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
E. coli
His
15.4 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
HEK 293 Cells
Myc-DDK (Flag)
67.5 kDa
20 µg/$1,107
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Human F2 / Prothrombin / Thrombin Protein (Recombinant 6His-SUMO, N-terminus) (aa44-622) - LS-G56250
E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
E. coli
His
35.5 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
E. coli
His
19.4 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
E. coli
His
35.6 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
E. coli
His
15.4 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Wheat Germ Extract
GST
96.4 kDa
2 µg/$439
E. coli
His, N-Terminal
20kDa
10 µg/$385; 50 µg/$962; 200 µg/$1,623; 100 µg/$1,388; 1 mg/$3,073; 500 µg/$2,450; 5 mg/$6,721; 2 mg/$3,585
293T Cells
Myc-DDK (Flag)
70.01 kDa
20 µg/$150
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
69.3 kDa
20 µg/$603
HEK 293 Cells
Myc-DDK (Flag)
70.01 kDa
100 µg/$494
E. coli
None
100 µg/$361; 500 µg/$739; 20 µg/$261
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