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F2 / Prothrombin / Thrombin

coagulation factor II (thrombin)

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

Gene Name: coagulation factor II (thrombin)
Family/Subfamily: Protease , Serine S1
Synonyms: F2, Prothrombin B-chain, Coagulation factor II, FACTOR II, Prothrombin, PT, RPRGL2, Serine protease, THPH1, Thrombin
Target Sequences: NM_000506 NP_000497.1 P00734

Publications (3)

1
Targeting the thrombin receptor modulates inflammation and astrogliosis to improve recovery after spinal cord injury. Radulovic M, Yoon H, Wu J, Mustafa K, Scarisbrick IA. Neurobiology of disease. 2016 93:226-42. (WB; Human) [Full Text Article] [PubMed:27145117] Related Antibodies: LS-C118750.
2
Production and control of coagulation proteins for factor X activation in human endothelial cells and fibroblasts. Clay T Cohen, Nancy A Turner, Joel L Moake. Scientific reports. 2020 Feb;10:2005. [Full Text Article] [PubMed:32029851] [PMC:PMC7005260]
3
Maternal plasma proteomics in a rat model of pregnancy complications reveals immune and pro-coagulant gene pathway activation. Tino W Sanchez, Bo Li, Christine Molinaro, Carlos A Casiano, Denise L Bellinger, Eugenia Mata-Greenwood. American journal of reproductive immunology (New York, N.Y. : 1989). 2020 February;83:e13205. [Full Text Article] [PubMed:31677200] [PMC:PMC8553409]

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F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Microplate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Microplate
Human
9.375 - 600 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
F2 / Prothrombin / Thrombin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
2.5 - 50 mg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1 - 500 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Media, Plasma, Serum, Tissue Extracts
1 Plate/$594
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1 - 500 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Media, Plasma, Serum, Tissue Extracts
1 Plate/$743
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
4.69 - 300 ng/ml
Colorimetric - 450nm (TMB)
Serum
1 Plate/$764
F2 / Prothrombin / Thrombin ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
9.375 - 600 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
F2 / Prothrombin / Thrombin ELISA Kit
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Competitive EIA
96-Well Microplate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$1,023
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Serum
1 Plate/$889
F2 / Prothrombin / Thrombin ELISA Kit
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Development Kit
Antibody Pair and Standard
Mouse
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma
500 Wells/$1,207; 1000 Wells/$1,787
F2 / Prothrombin / Thrombin ELISA Kit
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Development Kit
Antibody Pair and Standard
Rat
15.6 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Serum
500 Wells/$1,254; 1000 Wells/$1,867
F2 / Prothrombin / Thrombin ELISA Kit
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Development Kit
Antibody Pair and Standard
Bovine
9.38 - 600 ng/ml
Colorimetric - 450nm (TMB)
Serum
500 Wells/$1,357; 1000 Wells/$2,039
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Sandwich
96-Well Strip Plate
Cow
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Serum
1 Plate/$929
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Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$783
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).