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EZR / Ezrin

ezrin

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.

Gene Name: ezrin
Synonyms: EZR, CVIL, Cytovillin, CVL, p81, VIL2, Villin 2 (ezrin), Villin-2, Cytovillin 2, Ezrin
Target Sequences: NM_003379 NP_003370.2 P15311

Publications (1)

1
MicroRNA-183 regulates Ezrin expression in lung cancer cells. Wang G, Mao W, Zheng S. FEBS letters. 2008 582:3663-8. (WB) [PubMed:18840437]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).