EZH2

enhancer of zeste homolog 2 (Drosophila)

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.

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Products

Proteins (12)

Type

Over-Expression Lysate (6)

Recombinant (6)

Target

EZH2 (12)

Publications

No (12)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (7)

Species

Human (9)

Source

293T Cells (3)

E. coli (3)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human EZH2 Protein (Recombinant His-T7) (aa559-747) - LS-G26049

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.1 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Human EZH2 Protein (Recombinant GST) (Full Length) - LS-G28409

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

112.4 kDa

Price:

2 µg/$439

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Human EZH2 Protein (Recombinant 6His, N-terminus) (aa51-285) - LS-G16069

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

28.5 kDa

Price:

10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$4,161

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EZH2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G127428

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.9 kDa

Price:

100 µg/$710

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EZH2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105967

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.9 kDa

Price:

100 µg/$710

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Human EZH2 Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G58509

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human EZH2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68217

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.8 kDa

Price:

20 µg/$1,107

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Human EZH2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81679

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.8 kDa

Price:

20 µg/$150

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Human EZH2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81682

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.9 kDa

Price:

20 µg/$215

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Human EZH2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81681

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.9 kDa

Price:

20 µg/$215

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EZH2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100299

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.8 kDa

Price:

100 µg/$494

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Human EZH2 Protein (Recombinant His, N-Terminal) (Arg494-Val737) - LS-G132980

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

29.2kDa

Price:

10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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