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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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EZH2

enhancer of zeste homolog 2 (Drosophila)

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.

Gene Name: enhancer of zeste homolog 2 (Drosophila)
Synonyms: EZH2, ENX1, Enhancer of zeste homolog 2, KMT6, KMT6A, Lysine N-methyltransferase 6, WVS2, Enhancer of zeste, ENX-1
Target Sequences: NM_004456 NP_004447.2 Q15910

Viewing 1-25 of 90 items
EZH2 Antibody - Anti-EZH2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human EZH2
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
EZH2 Antibody - Anti-EZH2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   0.25mg/ml   $485.00
EZH2 Antibody - EZH2 Monoclonal Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human testis tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
Mouse Monoclonal (IgG1,k) to Human EZH2
Human
IF, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
EZH2 Antibody
Select
Rabbit Polyclonal to Human EZH2
Mouse, Human
ICC, IF, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $275.00
Select
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, ICC, IF, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200µl   $740.00
Select
Mouse Monoclonal (IgG1,k) to Human EZH2
Mouse, Human
WB
Unconjugated
100µg   $770.00
Select
Rabbit Polyclonal (IgG) to Human EZH2
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $295.00; 200µl   $385.00
Select
Rabbit Polyclonal to Human EZH2
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Hamster, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
IHC, WB
Unconjugated
100µl   0.5mg/ml   $365.00
Select
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ICC, IF, IHC, WB
Unconjugated
200µl   $590.00
Select
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ELISA, ICC, IF, IHC, WB
AP Conjugated
200µl   $740.00
Select
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200µl   $740.00
Select
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, IF, IP, WB
Unconjugated
100µg   $355.00
EZH2 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-EZH2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI2B10] (IgG1) to Human EZH2
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
EZH2 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-EZH2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI2B10] (IgG1) to Human EZH2
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
Select
Rabbit Polyclonal (IgG) to Human EZH2
Rabbit, Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00

Viewing 1-25 of 90 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).