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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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EZH2

enhancer of zeste homolog 2 (Drosophila)

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.

Gene Name: enhancer of zeste homolog 2 (Drosophila)
Synonyms: EZH2, ENX1, Enhancer of zeste homolog 2, KMT6, KMT6A, Lysine N-methyltransferase 6, WVS2, Enhancer of zeste, ENX-1
Target Sequences: NM_004456 NP_004447.2 Q15910

Filtered by: None
Target
EZH2 (92)
Reactivity
Human (92)
Mouse (31)
Rat (11)
Bat (4)
Bovine (4)
Chicken (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (4)
Hamster (4)
Horse (4)
Monkey (4)
Pig (4)
Primate (1)
Rabbit (11)
Xenopus (4)
Zebrafish (4)
Application
IHC (41)
IHC-Fr (1)
IHC-P (6)
WB (85)
Flo (8)
ChrIP (1)
ELISA (32)
ICC (15)
IF (21)
IP (5)
Peptide-ELISA (1)
Host
rabbit (68)
mouse (24)
Isotype
IgG (42)
IgG1 (5)
IgG1,k (15)
IgG2b (2)
IgG2b,k (1)
Clonality
monoclonal mc (23)
polyclonal pc (69)
Clone
144CT2.1.1.5 (7)
2C3 (1)
6G4F4 (1)
OTI10B10 (2)
OTI2B10 (2)
UMAB264 (2)
Format
AP Conjugated (5)
APC (2)
APC Conjugated (7)
Azide-free (3)
Biotin Conjugated (8)
Carrier-free (3)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (8)
HRP Conjugated (8)
PE Conjugated (7)
Unconjugated (45)
Epitope
N-Terminus (13)
aa51-285 (8)
aa559-747 (8)
aa182-431 (6)
Internal (2)
aa1-250 (1)
aa1-286 (1)
aa1-343 (1)
aa175-225 (1)
aa260-295 (1)
aa696-746 (1)
pSer21 (1)
Publications
No (92)
Showing 1-25 of 92 results

IHC-plus™ EZH2 Antibody LS-B7096
Rabbit Polyclonal (IgG) to Human EZH2
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-EZH2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunocytochemistry of EZH2 in 293 cells with EZH2 antibody at 10 ug/ml.

IHC-plus™ EZH2 Antibody (Internal) LS-B2528
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg 0.25mg/ml  $485.00
Anti-EZH2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

EZH2 Antibody LS-C167873
Mouse Monoclonal (IgG1,k) to Human EZH2
Human
IF, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
EZH2 Monoclonal Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human testis tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Fluorescent image of U251 cell stained with EZH2 Antibody. U251 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with EZH2 primary antibody (1:25, 1 h at 37°C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-mouse antibody (green) was used (1:400, 50 min at 37°C). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37°C). EZH2 immunoreactivity is localized to Nucleus significantly.

IHC-plus™ EZH2 Antibody LS-B6702
Rabbit Polyclonal (IgG) to Human EZH2
Human
IHC, IHC-Fr, IHC-P
Unconjugated
125µl 0.24mg/ml  $495.00
Anti-EZH2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-EZH2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.

EZH2 Antibody LS-C668256
Rabbit Polyclonal to Human EZH2
Mouse, Human
ICC, IF, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $275.00
Immunofluorescence Image
Western blot Image

EZH2 Antibody LS-C321238
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200µl  $590.00

EZH2 Antibody (Biotin) LS-C214081
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200µl  $740.00

EZH2 Antibody (FITC) LS-C214082
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200µl  $740.00

EZH2 Antibody (APC) LS-C214080
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200µl  $740.00

EZH2 Antibody (AP) LS-C214079
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, ICC, IF, IHC, WB
AP Conjugated
200µl  $740.00

EZH2 Antibody (PE) LS-C214084
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200µl  $740.00

EZH2 Antibody (Azide-free, HRP) LS-C214083
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

EZH2 Antibody (aa1-286) LS-C125574
Mouse Monoclonal (IgG1,k) to Human EZH2
Mouse, Human
WB
Unconjugated
100µg  $770.00

EZH2 Antibody LS-C746880
Rabbit Polyclonal (IgG) to Human EZH2
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00

EZH2 Antibody (N-Terminus) LS-C151203
Rabbit Polyclonal to Human EZH2
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Hamster, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
IHC, WB
Unconjugated
100µl 0.5mg/ml  $365.00

EZH2 Antibody (clone 144CT2.1.1.5) LS-C319151
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ICC, IF, IHC, WB
Unconjugated
200µl  $590.00

EZH2 Antibody (clone 144CT2.1.1.5, Biotin) LS-C212439
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200µl  $740.00

EZH2 Antibody (clone 144CT2.1.1.5, FITC) LS-C212440
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200µl  $740.00

EZH2 Antibody (clone 144CT2.1.1.5, AP) LS-C212438
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ELISA, ICC, IF, IHC, WB
AP Conjugated
200µl  $740.00

EZH2 Antibody (clone 144CT2.1.1.5, Azide-free, HRP) LS-C212441
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

EZH2 Antibody (clone 144CT2.1.1.5, PE) LS-C212442
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200µl  $740.00

EZH2 Antibody (clone 144CT2.1.1.5, APC) LS-C221204
Mouse Monoclonal [clone 144CT2.1.1.5] (IgG1,k) to Human EZH2
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200µl  $740.00

EZH2 Antibody LS-C754700
Rabbit Polyclonal (IgG) to Human EZH2
Human
ELISA, IF, IP, WB
Unconjugated
100µg  $355.00

EZH2 Antibody (aa182-431, clone OTI2B10) LS-C338617
Mouse Monoclonal [clone OTI2B10] (IgG1) to Human EZH2
Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-EZH2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120°C for 3min).
IHC of paraffin-embedded Human lymphoma tissue using anti-EZH2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120°C for 3min).

EZH2 Antibody (aa182-431, clone OTI2B10, Carrier-free) LS-C789704
Mouse Monoclonal [clone OTI2B10] (IgG1) to Human EZH2
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-EZH2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120°C for 3min).
IHC of paraffin-embedded Human lymphoma tissue using anti-EZH2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120°C for 3min).
Showing 1-25 of 92 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).