EYA2

eyes absent homolog 2 (Drosophila)

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.

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Proteins (3)

Type

Recombinant (3)

Target

EYA2 (3)

Publications

No (3)

Tag

GST (1)

His (1)

His-SUMO (1)

Species

Human (3)

Source

E. coli (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human EYA2 Protein (Recombinant His-SUMO) (aa1-514) - LS-G20716

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

72.7 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human EYA2 Protein (Recombinant His) - LS-G1698

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human EYA2 Protein (Recombinant GST) (Full Length) - LS-G28410

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

85.6 kDa

Price:

2 µg/$439

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