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EYA1

eyes absent homolog 1 (Drosophila)

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2.

Gene Name: eyes absent homolog 1 (Drosophila)
Synonyms: EYA1, BOP, BOS1, Eyes absent homolog 1, BOR
Target Sequences: NM_000503 NP_000494.2 Q99502

Filtered By: None
Type
Recombinant (1)
Target
eya1 (1)
Tag
GST,N-terminus (1)
Species
Human (1)
Source
Wheat Germ Extract (1)
Showing 1-1 out of 1 results
Human EYA1 Protein (Recombinant GST,N-terminus) (aa100-170) - LS-G58507

Wheat Germ Extract
71 AA
GST,N-terminus
No
No known endotoxin level

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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