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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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EXOSC8

exosome component 8

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.

Gene Name: exosome component 8
Synonyms: EXOSC8, BA421P11.3, CBP-interacting protein 3, CIP3, Exosome component 8, EAP2, Opa interacting protein 2, p9, Rrp43p, RP11-421P11.3, OIP-2, OIP2, Opa-interacting protein 2, RRP43
Target Sequences: AF025438 AAC39558.1 Q96B26

Filtered By: None
Target
EXOSC8 (11)
Reactivity
Human (11)
Application
IHC (3)
IHC-P (2)
WB (6)
Flo (1)
DB (2)
ELISA (6)
IF (1)
Host
rabbit (7)
mouse (4)
Isotype
IgG (5)
IgG1 (3)
IgG1,k (1)
Clonality
monoclonal mc (4)
polyclonal pc (7)
Clone
1G5 (1)
2336C2b (2)
Format
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (8)
Epitope
aa243-276 (1)
Publications
No (11)
Showing 1-11 of 11 results

EXOSC8 Antibody LS-C665454
Rabbit Polyclonal (IgG) to Human EXOSC8
Human
ELISA IF IHC WB
Unconjugated
100µg  $335.00

EXOSC8 Antibody (aa243-276) LS-C97265
Rabbit Polyclonal to Human EXOSC8
Human
Flo IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human brain tissue with EXOSC8 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of anti-EXOSC8 Antibody in HL60 cell line lysates (35 ug/lane). EXOSC8(arrow) was detected using the purified antibody.
Formalin-fixed and paraffin-embedded human brain tissue with EXOSC8 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of anti-EXOSC8 Antibody in HL60 cell line lysates (35 ug/lane). EXOSC8(arrow) was detected using the purified antibody.

EXOSC8 Antibody (clone 1G5) LS-C133691
Mouse Monoclonal [clone 1G5] (IgG1,k) to Human EXOSC8
Human
ELISA IHC IHC-P WB
Unconjugated
100µg  $355.00
Immunoperoxidase of monoclonal antibody to EXOSC8 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]
EXOSC8 monoclonal antibody (M01), clone 1G5 Western blot of EXOSC8 expression in HeLa NE.
Immunoperoxidase of monoclonal antibody to EXOSC8 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]
EXOSC8 monoclonal antibody (M01), clone 1G5 Western blot of EXOSC8 expression in HeLa NE.

EXOSC8 Antibody (clone 2336C2b) LS-C342628
Mouse Monoclonal [clone 2336C2b] (IgG1) to Human EXOSC8
Human
DB WB
Unconjugated
100µg 0.1mg/ml  $375.00
Western blot analysis of immunized recombinant protein, using anti-EXOSC8 monoclonal antibody.
Western blot analysis of immunized recombinant protein, using anti-EXOSC8 monoclonal antibody.

EXOSC8 Antibody LS-C65798
Mouse Monoclonal (IgG1) to Human EXOSC8
Human
WB
Unconjugated
100µg  $545.00

EXOSC8 Antibody LS-C397756
Rabbit Polyclonal (IgG) to Human EXOSC8
Human
ELISA
Unconjugated
50µg  $285.00; 100µg  $385.00

EXOSC8 Antibody (HRP) LS-C397757
Rabbit Polyclonal (IgG) to Human EXOSC8
Human
ELISA
HRP Conjugated
50µg  $285.00; 100µg  $385.00

EXOSC8 Antibody (Biotin) LS-C397759
Rabbit Polyclonal (IgG) to Human EXOSC8
Human
ELISA
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

EXOSC8 Antibody (FITC) LS-C397758
Rabbit Polyclonal (IgG) to Human EXOSC8
Human
ELISA
FITC Conjugated
50µg  $285.00; 100µg  $385.00

EXOSC8 Antibody (clone 2336C2b) LS-C184596
Mouse Monoclonal [clone 2336C2b] (IgG1) to Human EXOSC8
Human
DB
Unconjugated
50µg 0.1mg/ml  $325.00

EXOSC8 Antibody LS-C668143
Rabbit Polyclonal to Human EXOSC8
Human
WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $275.00
Western blot Image
Western blot Image
Showing 1-11 of 11 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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