EXOSC6

exosome component 6

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

EXOSC6 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human EXOSC6 Protein (Recombinant GST, N-terminus) (aa3-66) - LS-G63595

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human EXOSC6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92998

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.2 kDa

Price:

20 µg/$150

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EXOSC6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107940

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.2 kDa

Price:

100 µg/$494

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