EXOSC5

exosome component 5

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

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Products

Antibodies (13)

Proteins (6)

Type

Over-Expression Lysate (2)

Primary (13)

Recombinant (4)

Target

EXOSC5 (19)

Reactivity

Human (13)

Mouse (3)

Rat (3)

Bovine (3)

Dog (3)

Guinea pig (3)

Horse (3)

Pig (3)

Rabbit (3)

Application

IHC (5)

IHC-P (1)

WB (12)

ELISA (6)

IF (1)

IP (2)

Host

rabbit (11)

mouse (2)

Isotype

IgG (8)

IgG2a,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (12)

Clone

1E11 (1)

Format

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

Unconjugated (7)

Epitope

N-Terminus (4)

aa1-50 (1)

Publications

No (19)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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EXOSC5 Antibody LS-C379737

Antibody:

EXOSC5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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EXOSC5 Antibody (HRP) LS-C379736

Antibody:

EXOSC5 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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EXOSC5 Antibody (Biotin) LS-C379741

Antibody:

EXOSC5 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

EXOSC5 Antibody (FITC) LS-C379735

Antibody:

EXOSC5 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

EXOSC5 Antibody LS-C665451

Antibody:

EXOSC5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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EXOSC5 Antibody (clone 1E11) LS-C139344

Antibody:

EXOSC5 Mouse anti-Human Monoclonal (1E11) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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EXOSC5 Antibody LS-C307942

Antibody:

EXOSC5 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µg/$705

Select

EXOSC5 Antibody (aa1-50) LS-C290533

Antibody:

EXOSC5 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

EXOSC5 Antibody (N-Terminus) LS-C345411

Antibody:

EXOSC5 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

EXOSC5 Antibody (N-Terminus, HRP) LS-C441316

Antibody:

EXOSC5 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

EXOSC5 Antibody (N-Terminus, Biotin) LS-C441314

Antibody:

EXOSC5 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

EXOSC5 Antibody (N-Terminus, FITC) LS-C441315

Antibody:

EXOSC5 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

EXOSC5 Antibody LS-C310296

Antibody:

EXOSC5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

100 µl/$749

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Human EXOSC5 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G62875

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human EXOSC5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83679

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.1 kDa

Price:

20 µg/$150

Select

Human EXOSC5 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69030

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.1 kDa

Price:

20 µg/$1,107

Select

Human EXOSC5 Protein (Recombinant GST) (Full Length) - LS-G34599

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

51.59 kDa

Price:

10 µg/$479; 25 µg/$670

Select

EXOSC5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101642

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.1 kDa

Price:

100 µg/$494

Select

Human EXOSC5 Protein (Recombinant His) - LS-G1675

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

Viewing 1-19 of 19 product results

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