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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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EXOSC1 / CSL4

exosome component 1

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.

Gene Name: exosome component 1
Synonyms: EXOSC1, CGI-108, Exosomal core protein CSL4, Exosome complex component CSL4, HCsl4p, p13, RP11-452K12.9, SKI4, CSL4, Csl4p, Exosome component 1, Ski4p
Target Sequences: NM_016046 NP_057130.1 Q9Y3B2

Filtered By: None
Target
EXOSC1 / CSL4 (25)
Reactivity
Human (25)
Mouse (1)
Application
IHC (2)
IHC-P (1)
WB (21)
ELISA (19)
IF (1)
IP (1)
Host
rabbit (16)
mouse (9)
Isotype
IgG (15)
IgG1 (1)
IgG2b,k (7)
Clonality
monoclonal mc (8)
polyclonal pc (17)
Clone
1H8 (1)
Format
AP Conjugated (2)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (10)
Epitope
aa165-191 (8)
aa145-195 (1)
Publications
No (25)
Showing 1-25 of 25 results

EXOSC1 / CSL4 Antibody LS-C665445
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
ELISA IHC WB
Unconjugated
100µg  $335.00

EXOSC1 / CSL4 Antibody LS-C398214
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
ELISA IHC IHC-P
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human skin tissue using antibody at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human skin tissue using antibody at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at dilution of 1:100.

EXOSC1 / CSL4 Antibody (HRP) LS-C398216
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
ELISA
HRP Conjugated
50µg  $285.00; 100µg  $385.00

EXOSC1 / CSL4 Antibody (Biotin) LS-C398183
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
ELISA
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

EXOSC1 / CSL4 Antibody (FITC) LS-C398217
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
ELISA
FITC Conjugated
50µg  $285.00; 100µg  $385.00

EXOSC1 / CSL4 Antibody LS-C307452
Mouse Monoclonal (IgG2b,k) to Human EXOSC1 / CSL4
Human
ELISA WB
Unconjugated
100µg  $560.00

EXOSC1 / CSL4 Antibody (HRP) LS-C542036
Mouse Monoclonal (IgG2b,k) to Human EXOSC1 / CSL4
Human
ELISA WB
HRP Conjugated
100µl  $710.00

EXOSC1 / CSL4 Antibody (Biotin) LS-C521902
Mouse Monoclonal (IgG2b,k) to Human EXOSC1 / CSL4
Human
ELISA WB
Biotin Conjugated
100µl  $710.00

EXOSC1 / CSL4 Antibody (FITC) LS-C531947
Mouse Monoclonal (IgG2b,k) to Human EXOSC1 / CSL4
Human
ELISA WB
FITC Conjugated
100µl  $710.00

EXOSC1 / CSL4 Antibody (PE) LS-C650147
Mouse Monoclonal (IgG2b,k) to Human EXOSC1 / CSL4
Human
ELISA WB
PE Conjugated
100µl  $710.00

EXOSC1 / CSL4 Antibody (AP) LS-C503978
Mouse Monoclonal (IgG2b,k) to Human EXOSC1 / CSL4
Human
ELISA WB
AP Conjugated
100µl  $710.00

EXOSC1 / CSL4 Antibody (APC) LS-C513688
Mouse Monoclonal (IgG2b,k) to Human EXOSC1 / CSL4
Human
ELISA WB
APC Conjugated
100µl  $710.00

EXOSC1 / CSL4 Antibody (aa145-195) LS-C290532
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Mouse, Human
IP WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human EXOSC1 by Western Blot. Samples: Whole cell lysate from HeLa (15 and 50 ug), 293T (50 ug), and Jurkat (50 ug) cells. Antibodies: Affinity purified rabbit anti-EXOSC1 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Detection of Mouse EXOSC1 by Western Blot. Samples: Whole cell lysate (15 and 50 ug) from mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-EXOSC1 antibody used for WB at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Detection of Human EXOSC1 by Western Blot. Samples: Whole cell lysate from HeLa (15 and 50 ug), 293T (50 ug), and Jurkat (50 ug) cells. Antibodies: Affinity purified rabbit anti-EXOSC1 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Detection of Mouse EXOSC1 by Western Blot. Samples: Whole cell lysate (15 and 50 ug) from mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-EXOSC1 antibody used for WB at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

EXOSC1 / CSL4 Antibody (aa165-191) LS-C321228
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
ELISA WB
Unconjugated
200µl  $530.00

EXOSC1 / CSL4 Antibody (aa165-191, Biotin) LS-C214057
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
ELISA WB
Biotin Conjugated
200µl  $680.00

EXOSC1 / CSL4 Antibody (aa165-191, FITC) LS-C214058
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
ELISA WB
FITC Conjugated
200µl  $680.00

EXOSC1 / CSL4 Antibody (aa165-191, APC) LS-C214056
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
ELISA WB
APC Conjugated
200µl  $680.00

EXOSC1 / CSL4 Antibody (aa165-191, AP) LS-C214055
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
ELISA WB
AP Conjugated
200µl  $680.00

EXOSC1 / CSL4 Antibody (aa165-191, PE) LS-C214060
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
ELISA WB
PE Conjugated
200µl  $680.00

EXOSC1 / CSL4 Antibody (aa165-191, Azide-free, HRP) LS-C214059
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

EXOSC1 / CSL4 Antibody LS-C307450
Mouse Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
IF WB
Unconjugated
50µg  $560.00

EXOSC1 / CSL4 Antibody (clone 1H8) LS-C340518
Mouse Monoclonal [clone 1H8] (IgG1) to Human EXOSC1 / CSL4
Human
WB
Unconjugated
100µl 1mg/ml  $335.00
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY EXOSC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-EXOSC1 (1:2000).
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY EXOSC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-EXOSC1 (1:2000).

EXOSC1 / CSL4 Antibody (aa165-191) LS-C159577
Rabbit Polyclonal to Human EXOSC1 / CSL4
Human
WB
Unconjugated
400µl  $305.00
EXOSC1 Antibody western blot of 293 cell line lysates (35 ug/lane). The EXOSC1 Antibody detected the EXOSC1 protein (arrow).
EXOSC1 Antibody western blot of 293 cell line lysates (35 ug/lane). The EXOSC1 Antibody detected the EXOSC1 protein (arrow).

EXOSC1 / CSL4 Antibody LS-C497010
Rabbit Polyclonal (IgG) to Human EXOSC1 / CSL4
Human
WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Western blot analysis of extracts of various cell lines, using EXOSC1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
Western blot analysis of extracts of various cell lines, using EXOSC1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.

EXOSC1 / CSL4 Antibody LS-C668633
Rabbit Polyclonal to Human EXOSC1 / CSL4
Human
WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $275.00
Western blot Image
Western blot Image
Showing 1-25 of 25 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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